Characterization of the role of integrin α5β1 in platelet function, hemostasis and experimental thrombosis.
Fiche publication
Date publication
octobre 2021
Journal
Thrombosis and haemostasis
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GACHET Christian, Dr MANGIN Pierre
Tous les auteurs :
Janus-Bell E, Yakusheva A, Scandola C, Receveur N, Muhammad-Usman A, Mouriaux C, Bourdon C, Loubière C, Eckly A, Senis YA, Panteleev MA, Gachet C, Mangin PH
Lien Pubmed
Résumé
Integrins are key regulators of various platelet functions. The pathophysiological importance of most platelet integrins has been investigated, with the exception of α5β1, a receptor for fibronectin. The aim of this study was to characterize the role of α5β1 in megakaryopoiesis, platelet function, and to determine its importance in hemostasis and arterial thrombosis.
Référence
Thromb Haemost. 2021 Oct 1;: