The Long Road to Understanding RNAPII Transcription Initiation and Related Syndromes.
Fiche publication
Date publication
juin 2021
Journal
Annual review of biochemistry
Auteurs
Membres identifiés du Cancéropôle Est :
Dr EGLY Jean-Marc, Dr COMPE Emmanuel
Tous les auteurs :
Compe E, Egly JM
Lien Pubmed
Résumé
In eukaryotes, transcription of protein-coding genes requires the assembly at core promoters of a large preinitiation machinery containing RNA polymerase II (RNAPII) and general transcription factors (GTFs). Transcription is potentiated by regulatory elements called enhancers, which are recognized by specific DNA-binding transcription factors that recruit cofactors and convey, following chromatin remodeling, the activating cues to the preinitiation complex. This review summarizes nearly five decades of work on transcription initiation by describing the sequential recruitment of diverse molecular players including the GTFs, the Mediator complex, and DNA repair factors that support RNAPII to enable RNA synthesis. The elucidation of the transcription initiation mechanism has greatly benefited from the study of altered transcription components associated with human diseases that could be considered transcription syndromes.
Mots clés
RNA polymerase II, human diseases, transcription
Référence
Annu Rev Biochem. 2021 Jun 20;90:193-219