Receptor for Advanced Glycation End Products is Involved in Platelet Hyperactivation and Arterial Thrombosis during Chronic Kidney Disease.
Fiche publication
Date publication
juillet 2020
Journal
Thrombosis and haemostasis
Auteurs
Membres identifiés du Cancéropôle Est :
Pr NGUYEN Philippe, Dr TERRYN Christine
Tous les auteurs :
Ortillon J, Hézard N, Belmokhtar K, Kawecki C, Terryn C, Fritz G, Kauskot A, Schmidt AM, Rieu P, Nguyen P, Maurice P, Touré F
Lien Pubmed
Résumé
Chronic kidney disease (CKD) is associated with a high cardiovascular mortality due to increased rates of vascular lesions and thrombotic events, as well as serum accumulation of uremic toxins. A subgroup of these toxins (advanced glycation end products [AGEs] and S100 proteins) can interact with the receptor for AGEs (RAGE). In this study, we analyzed the impact of CKD on platelet function and arterial thrombosis, and the potential role of RAGE in this process.
Référence
Thromb. Haemost.. 2020 Jul 29;: