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Laboratory Monitoring of Heparin Anticoagulation in Hemodialysis: Rationale and Strategies.

Chiasakul T, Mullier F, Lecompte T, Nguyen P, Cuker A

Semin Nephrol. 2024 01 29;:151477

Identification of Heparin-Induced Thrombocytopenia in Surgical Critically Ill Patients by Using the HIT Expert Probability Score: An Observational Pilot Study.

Besch G, Ilic D, Ginet M, d'Audigier C, Nguyen P, Ferreira D, Samain E, Mourey G, Pili-Floury S

J Clin Med. 2022 Mar 10;11(6):

GFHT Proposals On The Practical Use Of Argatroban - With Specifics Regarding Vaccine-Induced Immune Thrombotic Thrombocytopaenia (VITT).

Siguret V, Boissier E, Maistre E, Gouin-Thibault I, James C, Lasne D, Mouton C, Godon A, Nguyen P, Lecompte T, Ajzenberg N, Bauters A, Béjot Y, Crassard I, Dahmani B, Desconclois C, Flaujac C, Frère C, Godier A, Gruel Y, Hézard N, Jourdi G, Kuadjovi C, Laurichesse M, Mémier V, Mourey G, Reiner P, Tardy B, Toussaint-Hacquard M

Anaesth Crit Care Pain Med. 2021 Oct 18;:100963

Prevention of venous thromboembolism and haemostasis monitoring in patients with COVID-19: Updated proposals (April 2021): From the French working group on perioperative haemostasis (GIHP) and the French study group on thrombosis and haemostasis (GFHT), i

Godon A, Tacquard CA, Mansour A, Garrigue D, Nguyen P, Lasne D, Testa S, Levy JH, Albaladejo P, Gruel Y, Susen S, Godier A,

Anaesth Crit Care Pain Med. 2021 Jun 25;:100919

Hypotheses behind the very rare cases of thrombosis with thrombocytopenia syndrome after SARS-CoV-2 vaccination.

Douxfils J, Favresse J, Dogné JM, Lecompte T, Susen S, Cordonnier C, Lebreton A, Gosselin R, Sié P, Pernod G, Gruel Y, Nguyen P, Vayne C, Mullier F

Thromb Res. 2021 May 15;203:163-171

Heparin-induced thrombocytopenia: construction of a pre-test diagnostic score derived from the analysis of a prospective multinational database, with internal validation.

Tardy-Poncet B, de Maistre E, Pouplard C, Presles E, Alhenc-Gelas M, Lasne D, Horellou MH, Mouton C, Serre-Sapin A, Bauters A, Nguyen P, Mullier F, Perrin J, Le Gal G, Morange PE, Grunebaum L, Lillo-Le Louet A, Elalamy I, Gruel Y, Greinacher A, Lecompte T, Tardy B,

J Thromb Haemost. 2021 Apr 19;:

Functional Flow Cytometric Assay for Reliable and Convenient Heparin-Induced Thrombocytopenia Diagnosis in Daily Practice.

Tardy-Poncet B, Montmartin A, Piot M, Alhenc-Gelas M, Nguyen P, Elalamy I, Greinacher A, Maistre E, Lasne D, Horellou MH, Le Gal G, Lecompte T, Tardy B, On Behalf Of The Gfht-Hit Study Group

Biomedicines. 2021 Mar 25;9(4):

A pilot study of procoagulant platelet extracellular vesicles and P-selectin increase during induction treatment in acute lymphoblastic leukaemia paediatric patients: two new biomarkers of thrombogenic risk?

Pluchart C, Barbe C, Poitevin G, Audonnet S, Nguyen P

J Thromb Thrombolysis. 2020 Nov 28;:

AgeR deletion decreases soluble fms-like tyrosine kinase 1 production and improves post-ischemic angiogenesis in uremic mice.

Dupont V, Al-Rifai R, Poitevin G, Ortillon J, Jayyosi L, Terryn C, Francois C, Rieu P, Fritz G, Boulagnon-Rombi C, Fichel C, Schmidt AM, Tournois C, Nguyen P, Touré F

Angiogenesis. 2020 Sep 23;:

Receptor for Advanced Glycation End Products is Involved in Platelet Hyperactivation and Arterial Thrombosis during Chronic Kidney Disease.

Ortillon J, Hézard N, Belmokhtar K, Kawecki C, Terryn C, Fritz G, Kauskot A, Schmidt AM, Rieu P, Nguyen P, Maurice P, Touré F

Thromb. Haemost.. 2020 Jul 29;:

Excess soluble fms-like tyrosine kinase 1 correlates with endothelial dysfunction and organ failure in critically ill COVID-19 patients.

Dupont V, Kanagaratnam L, Goury A, Poitevin G, Bard M, Julien G, Bonnivard M, Champenois V, Noel V, Mourvillier B, Nguyen P

Clin. Infect. Dis.. 2020 Jul 16;:

Prevention of thrombotic risk in hospitalized patients with COVID-19 and hemostasis monitoring.

Susen S, Tacquard CA, Godon A, Mansour A, Garrigue D, Nguyen P, Godier A, Testa S, Levy JH, Albaladejo P, Gruel Y,

Crit Care. 2020 Jun 19;24(1):364

Ticagrelor Prevents Endothelial Cell Apoptosis through the Adenosine Signalling Pathway in the Early Stages of Hypoxia.

Feliu C, Peyret H, Brassart-Pasco S, Oszust F, Poitevin G, Nguyen P, Millart H, Djerada Z

Biomolecules. 2020 May 9;10(5):

Real Life Population Pharmacokinetics Modelling of Eight Factors VIII in Patients with Severe Haemophilia A: Is It Always Relevant to Switch to an Extended Half-Life?

Allard Q, Djerada Z, Pouplard C, Repessé Y, Desprez D, Galinat H, Frotscher B, Berger C, Harroche A, Ryman A, Flaujac C, Chamouni P, Guillet B, Volot F, Szymezak J, Nguyen P, Cazaubon Y

Pharmaceutics. 2020 Apr 21;12(4):

In vivo efficacy of endothelial growth medium stimulated mesenchymal stem cells derived from patients with critical limb ischemia.

Al-Rifai R, Nguyen P, Bouland N, Terryn C, Kanagaratnam L, Poitevin G, François C, Boisson-Vidal C, Sevestre MA, Tournois C

J Transl Med. 2019 Aug 9;17(1):261

Subcutaneous and transcutaneous monitoring of murine hindlimb ischemia by in vivo Raman spectroscopy.

Al-Rifai R, Tournois C, Kheirallah S, Bouland N, Poitevin G, Nguyen P, Beljebbar A

Analyst. 2019 Jul 3;:

Vincristine induces procoagulant activity of the human lymphoblastic leukemia cell line Jurkat through the release of extracellular vesicles.

Pluchart C, Poitevin G, Colinart-Thomas M, Guimard G, Audonnet S, Terryn C, Nguyen P

J. Thromb. Thrombolysis. 2019 Jun 7;:

Complementary Role of P2 and Adenosine Receptors in ATP Induced-Anti-Apoptotic Effects Against Hypoxic Injury of HUVECs.

Feliu C, Peyret H, Poitevin G, Cazaubon Y, Oszust F, Nguyen P, Millart H, Djerada Z

Int J Mol Sci. 2019 Mar 22;20(6):

Management of antiplatelet therapy for non-elective invasive procedures or bleeding complications: Proposals from the French Working Group on Perioperative Haemostasis (GIHP) and the French Study Group on Thrombosis and Haemostasis (GFHT), in collaboratio

Godier A, Garrigue D, Lasne D, Fontana P, Bonhomme F, Collet JP, de Maistre E, Ickx B, Gruel Y, Mazighi M, Nguyen P, Vincentelli A, Albaladejo P, Lecompte T,

Arch Cardiovasc Dis. 2019 Jan 5;:

MANAGEMENT IF ANTIPLATELET THERAPY FOR NON-ELECTIVE INVASIVE PROCEDURES OF BLEEDING COMPLICATIONS: PROPOSALS FROM THE FRENCH WORKING GROUP ON PERIOPERATIVE HAEMOSTATSIS (GIHP) AND THE FRENCH STUDY GROUP ON THROMBOSIS AND HAEMOSTASIS (GFHT), IN COLLABORATI

Godier A, Garrigue D, Lasne D, Fontana P, Bonhomme F, Collet JP, de Maistre E, Ickx B, Gruel Y, Mazighi M, Nguyen P, Vincentelli A, Albaladejo P, Lecompte T

Anaesth Crit Care Pain Med. 2018 Oct 23;:

Determinants of adherence and consequences of the transition from adolescence to adulthood among young people with severe haemophilia (TRANSHEMO): study protocol for a multicentric French national observational cross-sectional study.

Resseguier N, Rosso-Delsemme N, Beltran Anzola A, Baumstarck K, Milien V, Ardillon L, Bayart S, Berger C, Bertrand MA, Biron-Andreani C, Borel-Derlon A, Castet S, Chamouni P, Claeyssens Donadel S, De Raucourt E, Desprez D, Falaise C, Frotscher B, Gay V, Goudemand J, Gruel Y, Guillet B, Harroche A, Hassoun A, Huguenin Y, Lambert T, Lebreton A, Lienhart A, Martin M, Meunier S, Monpoux F, Mourey G, Negrier C, Nguyen P, Nyombe P, Oudot C, Pan-Petesch B, Polack B, Rafowicz A, Rauch A, Rivaud D, Schneider P, Spiegel A, Stoven C, Tardy B, Trossaërt M, Valentin JB, Vanderbecken S, Volot F, Voyer-Ebrard A, Wibaut B, Leroy T, Sannie T, Chambost H, Auquier P

BMJ Open. 2018 Jul 25;8(7):e022409

Management of bleeding and emergency invasive procedures in patients on dabigatran: updated guidelines from the French Working Group on Perioperative Haemostasis (GIHP) - September 2016.

Albaladejo P, Pernod G, Godier A, de Maistre E, Rosencher N, Mas JL, Fontana P, Samama CM, Steib A, Schlumberger S, Marret E, Roullet S, Susen S, Madi-Jebara S, Nguyen P, Schved JF, Bonhomme F, Sié P

Anaesth Crit Care Pain Med. 2018 May 2;:

Autologous Bone Marrow Mononuclear Cell Implantation and Its Impact on the Outcome of Patients With Critical Limb Ischemia　- Results of a Randomized, Double-Blind, Placebo-Controlled Trial.

Pignon B, Sevestre MA, Kanagaratnam L, Pernod G, Stephan D, Emmerich J, Clement C, Sarlon G, Boulon C, Tournois C, Nguyen P

Circ. J.. 2017 Oct 25;81(11):1713-1720

New in vivo model to analyse the expression of angiogenic genes in the borders of a cleft lip.

François C, Poli-Merol ML, Tournois C, Cornillet-Lefebvre P, Guillard T, Djerada Z, Doco Fenzy M, Nguyen P

Br J Oral Maxillofac Surg. 2017 Mar;:

Cell therapy in critical limb ischemia: A comprehensive analysis of two cell therapy products.

Tournois C, Pignon B, Sevestre MA, Al-Rifai R, Creuza V, Poitevin G, François C, Nguyen P

Cytotherapy. 2017 Feb;19(2):299-310

Critical limb ischaemia and the response to bone marrow-derived cell therapy according to tcPO2 measurement.

Maufus M, Antoinette Sevestre-Pietri M, Sessa C, Pignon B, Egelhofer H, Dupas S, Nguyen P, Genty C, Pernod G

VASA. 2017 Jan;46(1):23-28

[Retrospective study of hypertensive leg ulcers at Reims University Hospital: Epidemiological, clinical, disease progression data, effects of vitamin K antagonists].

Nicol P, Bernard P, Nguyen P, Durlach A, Perceau G

Ann Dermatol Venereol. 2017 Jan;144(1):37-44

Tissue factor expressed by adherent cells contributes to hemodialysis-membrane thrombogenicity.

Lakbakbi S, Debrumetz A, Terryn C, Szymezak J, Rieu P, Nguyen P

Thromb. Res.. 2016 Aug;144:218-23

Fondaparinux upregulates thrombomodulin and the endothelial protein C receptor during early-stage reperfusion in a rat model of myocardial infarction.

Guillou S, Tamareille S, Giraud S, Poitevin G, Prunier-Mirebeau D, Nguyen P, Prunier F, Macchi L

Thromb. Res.. 2016 May;141:98-103

Human Neutrophils Support Thrombin Generation in Peritonitis.

Lakbakbi S, Debrumetz A, Rieu P, Nguyen P

Perit Dial Int. 2015 9-10;35(5):599-602.

Novel association between serum pentraxin-2 levels and advanced fibrosis in well-characterised patients with non-alcoholic fatty liver disease.

Verna EC, Patel J, Bettencourt R, Nguyen P, Hernandez C, Valasek MA, Kisselva T, Brenner DA, Loomba R

Aliment. Pharmacol. Ther.. 2015 Sep;42(5):582-90

Critical limb ischemia: thrombogenic evaluation of two autologous cell therapy products and biologic profile in treated patients.

Tournois C, Pignon B, Sevestre MA, Djerada Z, Capiod JC, Poitevin G, Delloup AM, Nguyen P

Transfusion. 2015 Jul 29

[New oral anticoagulants and prostate biopsy: Which usual precaution should we use?].

Coscarella M, Viart L, Nguyen P, Saint F

Prog. Urol.. 2015 Jul;25(9):510-5

Anticoagulation in Chronic Hemodialysis: Progress Toward an Optimal Approach.

Kessler M, Moureau F, Nguyen P

Semin Dial. 2015 Apr 25

Argatroban in the management of heparin-induced thrombocytopenia: a multicenter clinical trial.

Tardy-Poncet B, Nguyen P, Thiranos JC, Morange PE, Biron-Andreani C, Gruel Y, Morel J, Wynckel A, Grunebaum L, Villacorta-Torres J, Grosjean S, de Maistre E

Crit Care. 2015 Nov 11;19:396

Elastin-derived peptides are new regulators of thrombosis.

Kawecki C, Hezard N, Bocquet O, Poitevin G, Rabenoelina F, Kauskot A, Duca L, Blaise S, Romier B, Martiny L, Nguyen P, Debelle L, Maurice P

Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2570-8

Venous thromboembolism: What pharmacists know? What do they need?

Rey JB, Jovenin N, Kreit P, Sicard J, Parent D, Hettler D, Nguyen P, Ducrocq JL

J Oncol Pharm Pract. 2014 Nov 25. pii: 1078155214560639.

[Proper use of apixaban: An outline for clinical practice.]

Albaladejo P, Deplanque D, Fossati F, Mahagne MH, Mismetti P, Nguyen P, Roy P, Touze E, Mourad JJ

J Mal Vasc. 2014 Nov 6. pii: S0398-0499(14)00239-X

Role of angiogenesis-related genes in cleft lip/palate: Review of the literature.

Francois-Fiquet C, Poli-Merol ML, Nguyen P, Landais E, Gaillard D, Doco-Fenzy M

Int J Pediatr Otorhinolaryngol. 2014 Aug 12. pii: S0165-5876(14)00445-5

Haemodialysis in patients treated with oral anticoagulant: should we heparinize?

Krummel T, Scheidt E, Borni-Duval C, Bazin D, Lefebvre F, Nguyen P, Hannedouche T

Nephrol Dial Transplant. 2014 Apr;29(4):906-13

Synthesis and conclusion.

Nguyen P

Oncologie. 2012 Dec;14(12):667-70.

[Questions--answers on the use of rivaroxaban for the treatment of venous thromboembolic disease].

Pernod G, Elias A, Gouin I, Gaillard C, Nguyen P, Ouvry P, Sie P

J Mal Vasc. 2012 Dec;37(6):300-10

Pharmacokinetics of fondaparinux 1.5 mg once daily in a real-world cohort of patients with renal impairment undergoing major orthopaedic surgery.

Delavenne X, Zufferey P, Nguyen P, Rosencher N, Samama CM, Bazzoli C, Mismetti P, Laporte S

Eur J Clin Pharmacol. 2012 Oct;68(10):1403-10

Anticoagulant properties of the anti-inflammatory cytokine IL-10 in a factor Xa-activated human monocyte model.

Ben-Hadj-Khalifa S, Nguyen P, Mahjoub T, Hezard N

Eur Cytokine Netw. 2012 Jul-Sep;23(3):87-92.

Venous thromboembolism prevention with fondaparinux 1.5 mg in renally impaired patients undergoing major orthopaedic surgery. A real-world, prospective, multicentre, cohort study.

Mismetti P, Samama CM, Rosencher N, Vielpeau C, Nguyen P, Deygas B, Presles E, Laporte S

Thromb Haemost. 2012 Jun;107(6):1151-60

Interleukin-10 promoter microsatellite polymorphisms influence the immune response to heparin and the risk of heparin-induced thrombocytopenia.

Pouplard C, Cornillet-Lefebvre P, Attaoua R, Leroux D, Lecocq-Lafon C, Rollin J, Grigorescu F, Nguyen P, Gruel Y

Thromb Res. 2012 Apr;129(4):465-9

IL-10 modulates fondaparinux inhibition of monocyte-induced thrombin generation.

Ben-Hadj-Khalifa S, Hezard N, Almawi WY, Lakbakbi S, Mace C, Cornillet-Lefebvre P, Mahjoub T, Nguyen P

J Thromb Thrombolysis. 2011 Oct;32(3):311-7.

[Necrotic leg ulcers induced by vitamin K antagonists: five cases].

Bezier M, Perceau G, Reguiai Z, Remy-Leroux V, Tchen T, Durlach A, Grange F, Nguyen P, Bernard P

Ann Dermatol Venereol. 2011 Oct;138(10):657-63.

Differential coagulation inhibitory effect of fondaparinux, enoxaparin and unfractionated heparin in cell models of thrombin generation.

Ben-Hadj-Khalifa S, Hezard N, Almawi WY, Remy MG, Florent B, Mahjoub T, Nguyen P

Blood Coagul Fibrinolysis. 2011 Jul;22(5):369-73.

Differential inhibitory effect of fondaparinux on the procoagulant potential of intact monocytes and monocyte-derived microparticles.

Ben-Hadj-Khalifa-Kechiche S, Hezard N, Poitevin S, Remy MG, Florent B, Mahjoub T, Nguyen P

J Thromb Thrombolysis. 2010 Nov;30(4):412-8.

Tissue factor up-regulation in proinflammatory conditions confers thrombin generation capacity to endothelial colony-forming cells without influencing non-coagulant properties in vitro.

Cuccuini W, Poitevin S, Poitevin G, Dignat-George F, Cornillet-Lefebvre P, Sabatier F, Nguyen P

J Thromb Haemost. 2010 Sep;8(9):2042-52

Population pharmacokinetics of fondaparinux administered at prophylactic doses after major orthopaedic surgery in everyday practice.

Delavenne X, Zufferey P, Baylot D, Nguyen P, Borg JY, Fontenay M, Deygas B, Mismetti P, Laporte S

Thromb Haemost. 2010 Aug 2;104(2):252-60

Risk factors for unfavorable clinical outcome in patients with documented heparin-induced thrombocytopenia.

Elalamy I, Tardy-Poncet B, Mulot A, de Maistre E, Pouplard C, Nguyen P, Cleret B, Gruel Y, Lecompte T, Tardy B

Thromb Res. 2009 Nov;124(5):554-9

IL-10 inhibits apoptosis and microvesiculation of human monocytes.

Poitevin S, Ben Hadj Kalifa Kechiche S, Mace C, Nguyen P

J Thromb Haemost. 2009 Jul;7(7):1241-3.

Interleukin 10 gene promoter polymorphisms in women with pregnancy loss: preferential association with embryonic wastage.

Cochery-Nouvellon E, Nguyen P, Attaoua R, Cornillet-Lefebvre P, Mercier E, Vitry F, Gris JC

Biol Reprod. 2009 Jun;80(6):1115-20

Characterization and comparison of bone marrow and peripheral blood mononuclear cells used for cellular therapy in critical leg ischaemia: towards a new cellular product.

Capiod JC, Tournois C, Vitry F, Sevestre MA, Daliphard S, Reix T, Nguyen P, Lefrere JJ, Pignon B

Vox Sang. 2009 Apr;96(3):256-65

[Resistance to platelet antiaggregants: the cardiologist's point of view]

Metz D, Hezard N, Duval S, Tassan-Mangina S, Deschildre A, Brasselet C, Nguyen P

J Mal Vasc. 2009 Feb;34(1):26-33

Use of rFVIIa in two children presenting major bleeding not controlled by the usual treatments before emergent surgery.

Guyot E, Carillion A, Poli-Merol ML, Ferrand I, Chauvet P, Nguyen P, Malinovsky JM

Paediatr Anaesth. 2008 Dec;18(12):1226-8.

Type I collagen induces tissue factor expression and matrix metalloproteinase 9 production in human primary monocytes through a redox-sensitive pathway.

Poitevin S, Garnotel R, Antonicelli F, Gillery P, Nguyen P

J Thromb Haemost. 2008 Sep;6(9):1586-94

[Spinal cord ischaemia and preoperative clopidogrel withdrawal in an arteriosclerotic patient]

Murat O, Durand E, Delepine G, Nguyen P, Malinovsky JM

Ann Fr Anesth Reanim. 2008 Apr;27(4):335-7

Is flow cytometry accurate enough to screen platelet autoantibodies?

Hezard N, Simon G, Mace C, Jallu V, Kaplan C, Nguyen P

Transfusion. 2008 Mar;48(3):513-8

A case control study of deep venous thrombosis in relation to factor V G1691A (Leiden) and A4070G (HR2 Haplotype) polymorphisms

Bouaziz-Borgi L, Nguyen P, Hezard N, Musharrafieh U, Almawi WY, Ou TM

Exp Mol Pathol. 2007 Dec;83(3):480-3

Thrombosis and renal transplantation : can we prevent the renal allograft thrombosis ?

Szymezak J, Houdant N, Toupance O, Brandt B, Nguyen P

Sang Thromb Vaiss. 2007 Sep;19(7):359-65

Monocyte IL-10 produced in response to lipopolysaccharide modulates thrombin generation by inhibiting tissue factor expression and release of active tissue factor-bound microparticles.

Poitevin S, Cochery-Nouvellon E, Dupont A, Nguyen P

Thromb Haemost. 2007 Apr;97(4):598-607.

IL-4 modulates tissue factor expression by human B lymphocytes in response to phorbol myristate acetate

Mechiche H, Nguyen P

Thromb Haemost. 2007 Jan;97(1):158-9.

Interleukin-10 promoter polymorphism and venous thrombosis: a case-control study.

Cochery-Nouvellon E, Vitry F, Cornillet-Lefebvre P, Hezard N, Gillot L, Nguyen P

Thromb Haemost. 2006 Jul;96(1):24-8.

Utility of thrombin-generation assay in the screening of factor V G1691A (Leiden) and prothrombin G20210A mutations and protein S deficiency.

Hezard N, Bouaziz-Borgi L, Remy MG, Nguyen P

Clin Chem. 2006 Apr;52(4):665-70

Platelet VASP phosphorylation assessment in clopidogrel-treated patients: lack of agreement between Western blot and flow cytometry.

Hezard N, Metz D, Garnotel R, Simon G, Mace C, Koebel P, Nguyen P

Platelets. 2005 Dec;16(8):474-81.

Long-term incubation with IL-4 and IL-10 oppositely modifies procoagulant activity of monocytes and modulates the surface expression of tissue factor and tissue factor pathway inhibitor.

Paysant J, Soria C, Cornillet-Lefebvre P, Nguyen P, Lenormand B, Mishal Z, Vannier JP, Vasse M

Br J Haematol. 2005 Nov;131(3):356-65.

A subpopulation of human B lymphocytes can express a functional Tissue Factor in response to phorbol myristate acetate.

Mechiche H, Cornillet-Lefebvre P, Nguyen P

Thromb Haemost. 2005 Jul;94(1):146-54.

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