Cascade: a R package to study, predict and simulate the diffusion of a signal through a temporal gene network.
Fiche publication
Date publication
février 2014
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BAHRAM Siamak, Dr VALLAT Laurent
Tous les auteurs :
Jung N, Bertrand F, Bahram S, Vallat L, Maumy-Bertrand M
Lien Pubmed
Résumé
SUMMARY: Temporal gene interactions, in response to environmental stress, form a complex system that can be efficiently described using gene regulatory networks. They allow highlighting the more influential genes and spotting some targets for biological intervention experiments. Despite that many reverse engineering tools have been designed, the Cascade package is an integrated solution adding several new and original key features such as the ability to predict changes in gene expressions after a biological perturbation in the network and graphical outputs that allow monitoring the spread of a signal through the network. AVAILABILITY AND IMPLEMENTATION: The R package Cascade is available online at http://www-math.u-strasbg.fr/genpred/spip.php?rubrique4.
Référence
Bioinformatics. 2014 Feb 15;30(4):571-3