Medicarpin and millepurpan, two flavonoids isolated from Medicago sativa, induce apoptosis and overcome multidrug resistance in leukemia P388 cells.
Fiche publication
Date publication
décembre 2015
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MORJANI Hamid, Dr EL BTAOURI Hassan
Tous les auteurs :
Gatouillat G, Magid AA, Bertin E, El btaouri H, Morjani H, Lavaud C, Madoulet C
Lien Pubmed
Résumé
High consumption of flavonoids has been associated with a decrease risk of cancer. Alfalfa (Medicago sativa) leaves have been widely used in traditional medicine and is currently used as a dietary supplement because of their high nutrient content. We previously reported the cytotoxic activity of alfalfa leaf extracts against several sensitive and multidrug resistant tumor cell lines.
Mots clés
Animals, Apoptosis, drug effects, Caspases, metabolism, Cell Line, Tumor, drug effects, Doxorubicin, Drug Resistance, Multiple, drug effects, Drug Resistance, Neoplasm, drug effects, Flavonoids, pharmacology, Leukemia P388, metabolism, Medicago sativa, chemistry, Mice, Molecular Structure, P-Glycoprotein, metabolism, Plant Leaves, chemistry, Pterocarpans, pharmacology
Référence
Phytomedicine. 2015 Dec;22(13):1186-94