Triterpenes from Salvia argentea var. aurasiaca and their antibacterial and cytotoxic activities.
Fiche publication
Date publication
août 2019
Journal
Fitoterapia
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GANGLOFF Sophie, Pr MORJANI Hamid
Tous les auteurs :
Bechkri S, Magid AA, Voutquenne-Nazabadioko L, Djemaa B, Kabouche A, Lehbili M, Lakhal H, Abedini A, Gangloff SC, Morjani H, Kabouche Z
Lien Pubmed
Résumé
Five undescribed ursane-type triterpenes, identified as 1β,3β,15α-trihydroxy-urs-9(11)-12-diene (1), 1β,3β,15α,28-tetrahydroxy-urs-9(11),12-diene (2), 1β,3β-dihydroxy-urs-9(11),12-dien-28-al (3), 1β,3β,7β,15α,28-pentahydroxy-urs-12-ene (4), and 1β,3β,15α-trihydroxy-urs-11-en-28-al (5), together with five known compounds (6-10), were isolated from the acetone extract of the dried aerial parts of Salvia argentea L. var. aurasiaca (Pomel) Batt. et Trab. (Lamiaceae). Structures were elucidated on the basis of extensive spectroscopic analysis including HR-ESI-MS, 1D- and 2D-NMR techniques and comparison with literature data. The antibacterial evaluation of compounds 1-10 of the acetone extract of the dried aerial parts, in addition to nine compounds (11-19) previously isolated from the extract of the fresh aerial parts, by bioautography on Staphylococcus aureus followed by the determination of MIC values of active compounds by serial dilution technique against five bacteria, revealed that two compounds have an antibacterial effect comparable to antibiotics. The cytotoxic activity evaluation of compounds 1-19 showed that Six compounds exhibited an antiproliferative activity against K562 and HT1080 cells with IC values ranging from 30.25 to 70.32 μM.
Mots clés
Lamiaceae, Salvia argentea L. var. aurasiaca, Ursane triterpenes
Référence
Fitoterapia. 2019 Aug 8;:104296