Isolation and structure elucidation of cyclopeptide alkaloids from the leaves of Heisteria parvifolia.
Fiche publication
Date publication
août 2019
Journal
Phytochemistry
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MORJANI Hamid
Tous les auteurs :
Bitchi MB, Magid AA, Kabran FA, Yao-Kouassi PA, Harakat D, Morjani H, Tonzibo FZ, Voutquenne-Nazabadioko L
Lien Pubmed
Résumé
Heisteria parvifolia Sm. is prescribed in traditional medecine against numerous diseases in Côte d'Ivoire. Due to the shortcoming in scientifical knowledge of use of this species, our investigations revealed five undescribed cyclopeptide alkaloids added to one known derivative namely anorldianine. These compounds were elucidated by 1D and 2D-NMR experiments and comparison with literature data, and confirmed by HR-ESI-MS. Cytotoxic activity evaluation of these compounds against the chronic myeloid leukemia (K565) cell line exhibited an antiproliferative activity with cell growth inhibition from 13% to 46%.
Mots clés
Chronic myeloid leukemia (K565) cell line, Cyclopeptide alkaloids, Cytotoxic activity, Heisteria parvifolia, Olacaceae
Référence
Phytochemistry. 2019 Aug 9;167:112081