Nucleotide Excision Repair and Transcriptional Regulation: TFIIH and Beyond.
Fiche publication
Date publication
juin 2016
Journal
Annual review of biochemistry
Auteurs
Membres identifiés du Cancéropôle Est :
Dr EGLY Jean-Marc, Dr COMPE Emmanuel
Tous les auteurs :
Compe E, Egly JM
Lien Pubmed
Résumé
Transcription factor IIH (TFIIH) is a multiprotein complex involved in both transcription and DNA repair, revealing a striking functional link between these two processes. Some of its subunits also belong to complexes involved in other cellular processes, such as chromosome segregation and cell cycle regulation, emphasizing the multitasking capabilities of this factor. This review aims to depict the structure of TFIIH and to dissect the roles of its subunits in different cellular mechanisms. Our understanding of the biochemistry of TFIIH has greatly benefited from studies focused on diseases related to TFIIH mutations. We address the etiology of these disorders and underline the fact that TFIIH can be considered a promising target for therapeutic strategies.
Référence
Annu. Rev. Biochem.. 2016 Jun;85:265-90