Cell surface expression of HLA I molecules as a marker of young platelets.
Fiche publication
Date publication
juin 2019
Journal
Journal of thrombosis and haemostasis : JTH
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GACHET Christian
Tous les auteurs :
Angénieux C, Dupuis A, Gachet C, de la Salle H, Maître B
Lien Pubmed
Résumé
Accurate identification of the proportion of young platelets is important to distinguish peripheral thrombocytopenia from a deficit in platelet production. Young platelets are defined by their higher RNA content and are often assessed as thiazole orange bright (TO ) by flow cytometry. In clinical practice, their proportion is estimated by automatic blood counter according to their greater RNA content which identify a so-called "immature" platelet fraction (IPF). However, the detected IPFs are not strictly identical to the young TO platelet population observed by flow cytometry.
Référence
J. Thromb. Haemost.. 2019 Jun 17;: