Activation of P-TEFb by RBM7: To Live or Let Die.
Fiche publication
Date publication
avril 2019
Journal
Molecular cell
Auteurs
Membres identifiés du Cancéropôle Est :
Dr COIN Frédéric, Dr LE MAY Nicolas
Tous les auteurs :
Le May N, Coin F
Lien Pubmed
Résumé
In this issue of Molecular Cell, Bugai et al. (2019) unveil that a key step of the pro-survival cellular response to a genotoxic attack is the activation of P-TEFb by RBM7. This crucial step triggers RNA polymerase II release from promoter-proximal pausing and expression of DNA damage response genes.
Référence
Mol. Cell. 2019 Apr 18;74(2):223-224