Is TFIIH the new Achilles heel of cancer cells?
Fiche publication
Date publication
août 2017
Journal
Transcription
Auteurs
Membres identifiés du Cancéropôle Est :
Dr COIN Frédéric
Tous les auteurs :
Berico P, Coin F
Lien Pubmed
Résumé
TFIIH is a ten-subunit complex involved in transcription and DNA repair. It contains several enzymatic activities including a ATP-dependent DNA translocase in XPB and a cyclin-dependent kinase in CDK7. Recently the discovery of several XPB and CDK7 inhibitors with specific impact on the transcriptional addiction of many tumors pinpointed these activities as potential target in cancer chemotherapy. Unexpectedly a basal transcription factor involved in global mRNA expression now emerges a one of the most clinically promising Achilles heels of cancerous cells. These inhibitors also proved to be useful tools to unveil new functions of TFIIH in gene expression.
Mots clés
DNA repair, TFIIH, genomic instability, helicase
Référence
Transcription. 2017 Aug;:0