Med1 deficiency alters the somatic hypermutation spectrum in murine B cells.
Fiche publication
Date publication
avril 2018
Journal
European journal of immunology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr REINA-SAN-MARTIN Bernardo
Tous les auteurs :
Gaudot L, Thomas-Claudepierre AS, Robert I, Schiavo E, Heyer V, Reina-San-Martin B
Lien Pubmed
Résumé
The Mediator complex is known to orchestrate transcription. Here we show that B cell conditional deficient mice for the Med1 subunit display robust somatic hypermutation. Nevertheless, the mutation frequency at A residues is decreased and the expected A/T ratio is abolished, implicating Mediator in the second phase of somatic hypermutation.
Mots clés
Activation-induced cytidine deaminase, Antibody diversification, B lymphocyte, Mediator, Somatic hypermutation
Référence
Eur. J. Immunol.. 2018 Apr;48(4):720-723