Reduced DICER1 Expression Bestows Rheumatoid Arthritis Synoviocytes Proinflammatory Properties and Resistance to Apoptotic Stimuli.
Fiche publication
Date publication
août 2016
Journal
Arthritis & rheumatology (Hoboken, N.J.)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BAHRAM Siamak, Dr PFEFFER Sébastien, Dr VALLAT Laurent, Pr GOTTENBERG Jacques-Eric
Tous les auteurs :
Alsaleh G, Nehmar R, Blüml S, Schleiss C, Ostermann E, Dillenseger JP, Sayeh A, Choquet P, Dembele D, Francois A, Salmon JH, Paul N, Schabbauer G, Bierry G, Meyer A, Gottenberg JE, Haas G, Pfeffer S, Vallat L, Sibilia J, Bahram S, Georgel P
Lien Pubmed
Résumé
While the regulatory role of individual microRNAs (miRNAs) in rheumatoid arthritis (RA) is well established, the role of DICER1 in the pathogenesis of the disease has not yet been investigated. The purpose of this study was to analyze the expression of factors involved in miRNA biogenesis in fibroblast-like synoviocytes (FLS) from RA patients and to monitor the arthritis triggered by K/BxN serum transfer in mice deficient in the Dicer gene (Dicer(d/d) ).
Mots clés
Animals, Apoptosis, Arthritis, Rheumatoid, genetics, DEAD-box RNA Helicases, genetics, Gene Expression Regulation, Humans, Inflammation, genetics, Mice, Ribonuclease III, genetics, Synoviocytes, physiology