Triterpenoid saponins from Scabiosa stellata collected in North-eastern Algeria.
Fiche publication
Date publication
juin 2018
Journal
Phytochemistry
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MORJANI Hamid
Tous les auteurs :
Lehbili M, Alabdul Magid A, Kabouche A, Voutquenne-Nazabadioko L, Morjani H, Harakat D, Kabouche Z
Lien Pubmed
Résumé
Eight undescribed triterpenoid saponins, scabiostellatosides A-H, together with three known compounds were isolated from the whole plant of Scabiosa stellata L. Their structures were established by spectroscopic analyses (1D, 2D-NMR and HRESIMS) and chemical methods. Scabiostellatosides A-H were evaluated for their cytotoxicity against human fibrosarcoma cell line (HT1080). Scabiostellatoside F, a heptasaccharide derivative of oleanolic acid, exhibited moderate cytotoxicity against HT1080 cell line with IC value of 12.0 μM.
Mots clés
Caprifoliaceae, Cytotoxic activity, Scabiosa stellata L., Triterpenoid saponins
Référence
Phytochemistry. 2018 Jun;150:40-49