A new 2-alkylhydroquinone glucoside from Phagnalon saxatile (L.) Cass.
Fiche publication
Date publication
septembre 2017
Journal
Natural product research
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MORJANI Hamid
Tous les auteurs :
Cherchar H, Lehbili M, Berrehal D, Morjani H, Alabdul Magid A, Voutquenne-Nazabadioko L, Kabouche A, Kabouche Z
Lien Pubmed
Résumé
A new 2-alkylhydroquinone glucoside, 1-O-β-d-glucopyranosyl-1,4-dihydroxy-2-((E) 2-oxo-3-butenyl)benzene (1), in addition to nine known compounds were isolated from the aerial parts of Phagnalon saxatile (L.) Cass. (Asteraceae). Their structures were identified based on spectroscopic methods including 1D and 2D NMR, mass spectrometry (HR-ESI-MS), UV spectral analyses and by comparison with literature data. The cytotoxic activity of three isolated compounds (1-3) was evaluated against fibrosarcoma (HT1080), human lung cancer (A549) and breast cancer (MCF7) cell lines.
Mots clés
Asteraceae, Phagnalon saxatile (L.) Cass, alkylhydroquinone glucoside, cytotoxic activity
Référence
Nat. Prod. Res.. 2017 Sep;:1-7