An introduction to matrikines: extracellular matrix-derived peptides which regulate cell activity. Implication in tumor invasion.
Fiche publication
Date publication
mars 2004
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BRASSART-PASCO Sylvie, Dr MONBOISSE Jean-Claude, Pr RAMONT Laurent
Tous les auteurs :
Maquart FX, Pasco S, Ramont L, Hornebeck W, Monboisse JC
Lien Pubmed
Résumé
The term of "matrikines" was coined for designating peptides liberated by partial proteolysis of extracellular matrix macromolecules, which are able to regulate cell activities. Among these peptides, some of them may modulate proliferation, migration, protease production, or apoptosis, which suggest that they can play a significant role in the control of tumor progression. In this introduction, we present the best characterized matrikines, derived from elastin, connective tissue glycoproteins, or collagens.
Référence
Crit Rev Oncol Hematol. 2004 Mar;49(3):199-202.