EN DE

Pr RAMONT Laurent

Fiche personne

coordonnées

Laboratoire de Biochimie Médicale et Biologie Moléculaire UFR de Médecine
51 rue Cognacq-Jay
51095 REIMS Cedex

03 26 78 33 49

lramont@chu-reims.fr

Territoire

Champagne-Ardenne

Statut

Hospitalo-Universitaire

affiliation

Centre Hospitalier Universitaire de Reims (CHU Reims)

Université de Reims Champagne-Ardenne (URCA)

UMR CNRS 7369 MEDyC - Matrice Extracellulaire et Dynamique Cellulaire MEDyC (MEDyC)

équipes/plateformes

Equipe UMR 7369 MEDyC - Equipe "Matrice extracellulaire, Cancer et Cibles thérapeutiques"

Recherche

Expertises :
- Recherche:Pharmacologie
- Recherche:Biologie Cellulaire
- Recherche:Biologie Moléculaire
- Recherche:Biochimie

Projets

Étude de nouveaux peptides à haut potentiel anti-tumoral dérivés du lumicane, conçus in silico, sur l'effet pro-invasif des exosomes dans la progression du cancer de l'ovaire par une approche transdisciplinaire

2022 - Porteur du projet : Pr RAMONT Laurent

Effets anti-angiogéniques du domaine NC1 du collagène XIX : détermination des mécanismes d’action sur les cellules endothéliales

2016 - Porteur du projet : Pr RAMONT Laurent

Publications

Investigation of Glypican-4 and -6 by Infrared Spectral Imaging during the Hair Growth Cycle.

Colin-Pierre C, Untereiner V, Sockalingum GD, Ramont L, Brézillon S

Int J Mol Sci. 2023 02 21;24(5):

High amylase concentration in drainage liquid can early predict proximal and distal intestinal anastomotic leakages: A prospective observational study.

Amroun K, Deguelte S, Djerada Z, Ramont L, Perrenot C, Rached L, Renard Y, Rhaiem R, Kianmanesh R

J Res Med Sci. 2023 01 31;28:5

An Innovative 3D-Printed Insert Designed to Enable Straightforward 2D and 3D Cell Cultures.

Colin-Pierre C, El Baraka O, Ramont L, Brézillon S

J Vis Exp. 2023 01 6;(191):

Regulation of stem cell fate by HSPGs: implication in hair follicle cycling.

Colin-Pierre C, El Baraka O, Danoux L, Bardey V, André V, Ramont L, Brézillon S

NPJ Regen Med. 2022 12 28;7(1):77

Differential MMP-14 Targeting by Biglycan, Decorin, Fibromodulin and Lumican Unraveled by In Silico Approach.

Rivet R, Rao RM, Nizet P, Belloy N, Huber L, Dauchez M, Ramont L, Baud S, Brézillon S

Am J Physiol Cell Physiol. 2022 12 19;:

Association between admission biomarkers and clinical outcome in older adults diagnosed with an infection in the emergency department.

Flamant L, Giordano Orsini G, Ramont L, Gornet M, De Ruffi S, Leroux P, Kanagaratnam L, Gennai S

Acta Clin Belg. 2022 11 17;:1-6

Increased intravitreal glucose in rhegmatogenous retinal detachment.

Arndt C, Hubault B, Hayate F, Barbe C, Afriat M, Gillery P, Ramont L, Henry A, Boulagnon-Rombi C

Eye (Lond). 2022 Mar 10;:

F4, a collagen XIX-derived peptide, inhibits tumor angiogenesis through αvβ3 and α5β1 integrin interaction.

Oudart JB, Villemin M, Brassart B, Sellier C, Terryn C, Dupont-Deshorgue A, Monboisse JC, Maquart FX, Ramont L, Brassart-Pasco S

Cell Adh Migr. 2021 Dec;15(1):215-223

Assessment of Ovarian Tumor Growth in Wild-Type and Lumican-Deficient Mice: Insights Using Infrared Spectral Imaging, Histopathology, and Immunohistochemistry.

Nizet P, Untereiner V, Sockalingum GD, Proult I, Terryn C, Jeanne A, Nannan L, Boulagnon-Rombi C, Sellier C, Rivet R, Ramont L, Brézillon S

Cancers (Basel). 2021 Nov 26;13(23):

Differential MMP-14 Targeting by Lumican-Derived Peptides Unraveled by In Silico Approach.

Dauvé J, Belloy N, Rivet R, Etique N, Nizet P, Pietraszek-Gremplewicz K, Karamanou K, Dauchez M, Ramont L, Brézillon S, Baud S

Cancers (Basel). 2021 Sep 30;13(19):

Analysis of 1635 procalcitonin prescriptions in the emergency department of a university hospital: A gap between evidence-based medicine and the real world?

De Ruffi S, Gornet M, Ramont L, Leroux P, Giordano Orsini G, Losset X, Kanagaratnam L, Gennai S

Int J Clin Pract. 2021 Jun;75(6):e14001

Lack of admission biomarkers' clinical utility in outcomes prediction in patients suspected with infection in the emergency department.

Gornet M, Leroux P, Ramont L, De Ruffi S, Giordano Orsini G, Losset X, Kanagaratnam L, Gennai S

Am J Emerg Med. 2021 Mar 26;47:109-114

Hair Histology and Glycosaminoglycans Distribution Probed by Infrared Spectral Imaging: Focus on Heparan Sulfate Proteoglycan and Glypican-1 during Hair Growth Cycle.

Colin-Pierre C, Untereiner V, Sockalingum GD, Berthélémy N, Danoux L, Bardey V, Mine S, Jeanmaire C, Ramont L, Brézillon S

Biomolecules. 2021 Jan 30;11(2):

Clinical Outcome Predictive Value of Procalcitonin in Patients Suspected with Infection in the Emergency Department.

Leroux P, De Ruffi S, Ramont L, Gornet M, Giordano Orsini G, Losset X, Kanagaratnam L, Gennai S

Emerg Med Int. 2021 ;2021:2344212

The Glypican-1/HGF/C-Met and Glypican-1/VEGF/VEGFR2 Ternary Complexes Regulate Hair Follicle Angiogenesis.

Colin-Pierre C, Berthélémy N, Belloy N, Danoux L, Bardey V, Rivet R, Mine S, Jeanmaire C, Maquart FX, Ramont L, Brézillon S

Front Cell Dev Biol. 2021 ;9:781172

Angiogenesis Inhibition by a Short 13 Amino Acid Peptide Sequence of Tetrastatin, the α4(IV) NC1 Domain of Collagen IV.

Vautrin-Glabik A, Devy J, Bour C, Baud S, Choulier L, Hoarau A, Dupont-Deshorgue A, Sellier C, Brassart B, Oudart JB, Ramont L, Monboisse JC, Brassart-Pasco S

Front Cell Dev Biol. 2020 ;8:775

Extracellular Vesicle-Dependent Cross-Talk in Cancer-Focus on Pancreatic Cancer.

Nannan L, Oudart JB, Monboisse JC, Ramont L, Brassart-Pasco S, Brassart B

Front Oncol. 2020 ;10:1456

Tumor Microenvironment: Extracellular Matrix Alterations Influence Tumor Progression.

Brassart-Pasco S, Brézillon S, Brassart B, Ramont L, Oudart JB, Monboisse JC

Front Oncol. 2020 ;10:397

Decreased expression of GPC1 in human skin keratinocytes and epidermis during ageing.

Perrot G, Colin-Pierre C, Ramont L, Proult I, Garbar C, Bardey V, Jeanmaire C, Mine S, Danoux L, Berthélémy N, Maquart FX, Wegrowski Y, Brézillon S

Exp. Gerontol.. 2019 Aug 17;:110693

Tumour cell blebbing and extracellular vesicle shedding: key role of matrikines and ribosomal protein SA.

Brassart B, Da Silva J, Donet M, Seurat E, Hague F, Terryn C, Velard F, Michel J, Ouadid-Ahidouch H, Monboisse JC, Hinek A, Maquart FX, Ramont L, Brassart-Pasco S

Br. J. Cancer. 2019 Feb 11;:

Conformation-dependent binding of a Tetrastatin peptide to αβ integrin decreases melanoma progression through FAK/PIK/Akt pathway inhibition.

Lambert E, Fuselier E, Ramont L, Brassart B, Dukic S, Oudart JB, Dupont-Deshorgue A, Sellier C, Machado C, Dauchez M, Monboisse JC, Maquart FX, Baud S, Brassart-Pasco S

Sci Rep. 2018 Jun 29;8(1):9837

Structural characterization and pro-tumor properties of a highly conserved matrikine.

Da Silva J, Lameiras P, Beljebbar A, Berquand A, Villemin M, Ramont L, Dukic S, Nuzillard JM, Molinari M, Gautier M, Brassart-Pasco S, Brassart B

Oncotarget. 2018 Apr 3;9(25):17839-17857

Characterization and Validation of a Three-Dimensional Multi-Cellular Culture Model to Study Heterotypic Interactions in Colorectal Cancer Cell Growth, Invasion and Metastasis.

Cattin S, Ramont L, Rüegg C

Front Bioeng Biotechnol. 2018 ;6:97

Tau protein as a possible marker of cerebrospinal fluid leakage in cerebrospinal fluid rhinorrhoea: A pilot study.

Oudart JB, Zucchini L, Maquart FX, Dubernard X, Labrousse M, Fiabane G, Quedreux A, Litre F, Ramont L

Biochem Med (Zagreb). 2017 Oct;27(3):030703

Confusing Hyperkalemia.

Manteaux AE, Dali-Braham I, Ramont L, Maquart FX, Oudart JB

Clin. Chem.. 2017 Jul;63(7):1305-1306

Type XIX collagen: A new partner in the interactions between tumor cells and their microenvironment.

Oudart JB, Monboisse JC, Maquart FX, Brassart B, Brassart-Pasco S, Ramont L

Matrix Biol.. 2017 Jan;57-58:169-177

Evaluation of Lumipulse® G1200 for the measurement of six tumor markers: Comparison with AIA® 2000.

de Rancher MR, Oudart JB, Maquart FX, Monboisse JC, Ramont L

Clin. Biochem.. 2016 Nov;49(16-17):1302-1306

Modifications to bicarbonate conductivity: A way to increase phosphate removal during hemodialysis? Proof of concept.

Bertocchio JP, Mohajer M, Gaha K, Ramont L, Maheut H, Rieu P

Hemodial Int. 2016 Oct;20(4):601-609

Aging decreases collagen IV expression in vivo in the dermo-epidermal junction and in vitro in dermal fibroblasts: possible involvement of TGF-β1.

Feru J, Delobbe E, Ramont L, Brassart B, Terryn C, Dupont-Deshorgue A, Garbar C, Monboisse JC, Maquart FX, Brassart-Pasco S

Eur J Dermatol. 2016 Aug;26(4):350-60

Milky Pleural Fluid.

Oudart JB, Pax C, Bennani-Smires B, Ramont L

Clin. Chem.. 2016 Feb;62(2):315-7

The anti-tumor NC1 domain of collagen XIX inhibits the FAK/ PI3K/Akt/mTOR signaling pathway through αvβ3 integrin interaction.

Oudart JB, Doué M, Vautrin A, Brassart B, Sellier C, Dupont-Deshorgue A, Monboisse JC, Maquart FX, Brassart-Pasco S, Ramont L

Oncotarget. 2016 Jan;7(2):1516-28

A competitive enzyme-linked immunosorbent assay for quantification of tetrastatin in body fluids and tumor extracts.

Dupont-Deshorgue A, Oudart JB, Brassart B, Deslee G, Perotin JM, Diebold MD, Monboisse JC, Ramont L, Brassart-Pasco S

Anal Biochem. 2015 Apr 29. pii: S0003-2697(15)00200-6

An acute monoclonal gammopathy?

Presle A, Bertocchio JP, Schneider N, Maquart FX, Ramont L, Oudart JB

Ann Biol Clin (Paris). 2015 Apr 1;73(2):185-189.

Endostatin level in cerebrospinal fluid of patients with Alzheimer's disease.

Salza R, Oudart JB, Ramont L, Maquart FX, Bakchine S, Thoannès H, Ricard-Blum S

J. Alzheimers Dis.. 2015 ;44(4):1253-61

Plasmin releases the anti-tumor peptide from the NC1 domain of collagen XIX.

Oudart JB, Brassart-Pasco S, Vautrin A, Sellier C, Machado C, Dupont-Deshorgue A, Brassart B, Baud S, Dauchez M, Monboisse JC, Harakat D, Maquart FX, Ramont L

Oncotarget. 2015 Jan 21.

Serum folate and vitamin B12: does light really matter?

Huguenin A, Oudart JB, Hubert J, Maquart FX, Ramont L

Clin. Chem. Lab. Med.. 2014 Sep;52(9):e203-4

Matrikines from basement membrane collagens: a new anti-cancer strategy.

Monboisse JC, Oudart JB, Ramont L, Brassart-Pasco S, Maquart FX

Biochim Biophys Acta. 2014 Aug;1840(8):2589-98

Interference of M-paraprotein in automated urea assays.

Oudart JB, Ok V, Faucon C, Zucchini L, Chiron A, Maquart FX, Ramont L

Clin Chem Lab Med. 2013 Jul;51(7):e153-5

Analytical methods for measuring collagen XIX in human cell cultures, tissue extracts, and biological fluids.

Oudart JB, Brassart-Pasco S, Luczka E, Dupont-Deshorgue A, Bellon G, Boudko SP, Bachinger HP, Monboisse JC, Maquart FX, Ramont L

Anal Biochem. 2013 Jun 15;437(2):111-7

A new anti-tumor strategy based on in vivo tumstatin overexpression after plasmid electrotransfer in muscle.

Thevenard J, Ramont L, Mir LM, Dupont-Deshorgue A, Maquart FX, Monboisse JC, Brassart-Pasco S

Biochem Biophys Res Commun. 2013 Mar 22;432(4):549-52

[Recommendations for the management of monoclonal gammopathies in biochemistry].

Oudart JB, Maquart FX, Ramont L

Ann Biol Clin (Paris). 2012 May-Jun;70(3):251-61.

Pleural effusion in a patient with multiple myeloma.

Oudart JB, Maquart FX, Semouma O, Lauer M, Arthuis-Demoulin P, Ramont L

Clin. Chem.. 2012 Apr;58(4):672-4

Tetrastatin, the NC1 domain of the alpha4(IV) collagen chain: a novel potent anti-tumor matrikine.

Brassart-Pasco S, Senechal K, Thevenard J, Ramont L, Devy J, Di Stefano L, Dupont-Deshorgue A, Brezillon S, Feru J, Jazeron JF, Diebold MD, Ricard-Blum S, Maquart FX, Monboisse JC

PLoS One. 2012;7(4):e29587

[Matrikines: a new anticancer therapeutic strategy].

Monboisse JC, Senechal K, Thevenard J, Ramont L, Brassart-Pasco S, Maquart FX

Biol Aujourdhui. 2012;206(2):111-23

[Hyperamylasemia after cardiac surgery: which significance?].

Oudart JB, Ledon S, Poncet A, Maquart FX, Ramont L

Ann Biol Clin (Paris). 2011 Mar-Apr;69(2):223-7.

The NC1 domain of type XIX collagen inhibits melanoma cell migration.

Toubal A, Ramont L, Terryn C, Brassart-Pasco S, Patigny D, Sapi J, Monboisse JC, Maquart FX

Eur J Dermatol. 2010 Nov-Dec;20(6):712-8

The YSNSG cyclopeptide derived from tumstatin inhibits tumor angiogenesis by down-regulating endothelial cell migration.

Thevenard J, Ramont L, Devy J, Brassart B, Dupont-Deshorgue A, Floquet N, Schneider L, Ouchani F, Terryn C, Maquart FX, Monboisse JC, Brassart-Pasco S

Int J Cancer. 2010 Mar 1;126(5):1055-66.

[Increased plasma C-reactive protein in a pregnant woman with multiple sclerosis: corticotherapy or not ?]

Limelette A, Caucheteux N, Ramont L, Tourbah A, Maquart FX

Ann Biol Clin (Paris). 2010 Mar-Apr;68(2):243-7.

Lumican inhibits B16F1 melanoma cell lung metastasis.

Brezillon S, Zeltz C, Schneider L, Terryn C, Vuillermoz B, Ramont L, Perrau C, Pluot M, Diebold MD, Radwanska A, Malicka-Blaszkiewicz M, Maquart FX, Wegrowski Y

J Physiol Pharmacol. 2009 Oct;60 Suppl 4:15-22.