Synthesis and anticancer activity of new pyrrolocarbazoles and pyrrolo-beta-carbolines.
Fiche publication
Date publication
mars 2005
Auteurs
Membres identifiés du Cancéropôle Est :
Pr SAPI Janos
Tous les auteurs :
Laronze M, Boisbrun M, Leonce S, Pfeiffer B, Renard P, Lozach O, Meijer L, Lansiaux A, Bailly C, Sapi J, Laronze JY
Lien Pubmed
Résumé
'Bended' 1, 3 or 'linear' 2 pyrrolidino-fused (aza)carbazoles were prepared and screened towards a few cancer-related targets. Whereas 'bended' derivatives 1 and 3 proved to be weakly toxic, several members of the 'linear' family strongly interact with DNA, especially derivative 28a.
Référence
Bioorg Med Chem. 2005 Mar 15;13(6):2263-83.