Rational design of vector and antibiotic peptides using solid-state NMR.
Fiche publication
Date publication
mai 2007
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BECHINGER Burkhard, Dr KICHLER Antoine
Tous les auteurs :
Mason AJ, Bechinger B, Kichler A
Lien Pubmed
Résumé
The application of 2H solid-state NMR in determining structure activity relationships and mechanism of action of membrane active peptides is discussed. The enhancement of the disruption of anionic lipids in the membrane by new lead compounds is shown to be a key determinant of both DNA vector and antimicrobial activity.
Référence
Mini Rev Med Chem. 2007 May;7(5):491-7.