TiCl4/Et3N-promoted three-component condensation between aromatic heterocycles, aldehydes, and active methylene compounds.
Fiche publication
Date publication
septembre 2008
Auteurs
Membres identifiés du Cancéropôle Est :
Pr SAPI Janos, Dr GERARD Stéphane
Tous les auteurs :
Renzetti A, Dardennes E, Fontana A, De Maria P, Sapi J, Gerard S
Lien Pubmed
Résumé
A one-pot methodology for the synthesis of polyfunctionalized indole derivatives by a TiCl4/Et3N-promoted trimolecular condensation of aldehydes, indole heterocycles, and various activated carbonyl compounds is reported. Rationalization of these reactions and extension to other heterocyclic systems is also described.
Référence
J Org Chem. 2008 Sep 5;73(17):6824-7