A new biomimetic route to engineer enzymatically active mechano-responsive materials.
Fiche publication
Date publication
février 2015
Auteurs
Membres identifiés du Cancéropôle Est :
Dr FRISCH Benoit, Dr LAVALLE Philippe, Pr SCHAAF Pierre
Tous les auteurs :
Rios C, Longo J, Zahouani S, Garnier T, Vogt C, Reisch A, Senger B, Boulmedais F, Hemmerle J, Benmlih K, Frisch B, Schaaf P, Jierry L, Lavalle P
Lien Pubmed
Résumé
Using modified beta-galactosidase covalently linked to cross-linked polyelectrolyte multilayers (PEM), catalytically active materials have been designed. Their enzymatic activity can be modulated, partially in a reversible way, simply by stretching. This strategy, based on enzyme conformational changes, constitutes a new tool for the development of biocatalytic mechano-responsive materials.
Référence
Chem Commun (Camb). 2015 Feb 26.