Novel powerful water-soluble lipid immunoadjuvants inducing mouse dendritic cell maturation and B cell proliferation using TLR2 pathway.
Fiche publication
Date publication
mars 2010
Auteurs
Membres identifiés du Cancéropôle Est :
Pr FOURNEL Sylvie, Dr FRISCH Benoit, Dr HEURTAULT Béatrice
Tous les auteurs :
Spanedda MV, Heurtault B, Weidner S, Baehr C, Boeglin E, Beyrath J, Milosevic S, Bourel-Bonnet L, Fournel S, Frisch B
Lien Pubmed
Résumé
Four novel water-soluble lipid immunoadjuvants were designed, synthesized and characterized by MS and NMR. They all induce mouse dendritic cell maturation and B cell proliferation. We demonstrate that in spite of the chemical modification, the four compounds remain TLR2 agonists.
Référence
Bioorg Med Chem Lett. 2010 Mar 15;20(6):1869-72