Aird EJ, Serrano-Benitez A, Siegner SM, Cannavo E, Belotserkovskaya R, Gueorguieva N, Fielden J, Cullot G, Ammann S, Bader AS, Gupta V, Andrieux G, Raab R, Del Rey González M, Cathomen T, Cejka P, Corn JE, Jackson SP

Nat Commun. 2026 02 25;17(1):

Genome editing with the HDR-enhancing DNA-PKcs inhibitor AZD7648 causes large-scale genomic alterations.

Cullot G, Aird EJ, Schlapansky MF, Yeh CD, van de Venn L, Vykhlyantseva I, Kreutzer S, Mailänder D, Lewków B, Klermund J, Montellese C, Biserni M, Aeschimann F, Vonarburg C, Gehart H, Cathomen T, Corn JE

Nat Biotechnol. 2025 11;43(11):1778-1782

Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes.

Gupta D, Patinios C, Bassett HV, Kibe A, Collins SP, Kamm C, Wang Y, Zhao C, Vollen K, Toussaint C, Calvin I, Cullot G, Aird EJ, Polkoff KM, Nguyen-Vo TP, Migur A, Schut F, Al'Abri IS, Achmedov T, Del Re A, Corn JE, Saliba AE, Crook N, Stepanova AN, Alonso JM, Beisel CL

Nat Biotechnol. 2025 09 4;:

Removal of TREX1 activity enhances CRISPR-Cas9-mediated homologous recombination.

Karasu ME, Toufektchan E, Chen Y, Albertelli A, Cullot G, Maciejowski J, Corn JE

Nat Biotechnol. 2025 07;43(7):1168-1176

Single-stranded HDR templates with truncated Cas12a-binding sequences improve knock-in efficiencies in primary human T cells.

Nitulescu AM, Du W, Glaser V, Kath J, Aird EJ, Cullot G, Greensmith R, Mikkelsen NS, Stein M, Bak RO, Kaminski M, Corn JE, Wagner DL

Mol Ther Nucleic Acids. 2025 06 10;36(2):102568

Asciminib resistance of a new BCR::ABL1 p.I293_K294insSSLRD mutant detected in a Ph + ALL patient.

Cullot G, Lagarde V, Cayuela JM, Prouzet-Mauléon V, Turcq B, Hicheri Y, Roy L, Braun T, Mozziconacci MJ, Alary AS, Dulucq S

Ann Hematol. 2025 02;104(2):1117-1126

Integrating allele-specific PCR with CRISPR-Cas13a for sensitive KRAS mutation detection in pancreatic cancer.

Amintas S, Cullot G, Boubaddi M, Rébillard J, Karembe L, Turcq B, Prouzet-Mauléon V, Bedel A, Moreau-Gaudry F, Cappellen D, Dabernat S

J Biol Eng. 2024 10 1;18(1):53

Cell cycle arrest and p53 prevent ON-target megabase-scale rearrangements induced by CRISPR-Cas9.

Cullot G, Boutin J, Fayet S, Prat F, Rosier J, Cappellen D, Lamrissi I, Pennamen P, Bouron J, Amintas S, Thibault C, Moranvillier I, Laharanne E, Merlio JP, Guyonnet-Duperat V, Blouin JM, Richard E, Dabernat S, Moreau-Gaudry F, Bedel A

Nat Commun. 2023 07 10;14(1):4072

Specific High-Sensitivity Enzymatic Reporter UnLOCKing-Mediated Detection of Oncogenic and Rearrangements.

Cullot G, Amintas S, Karembé L, Prouzet-Mauléon V, Rébillard J, Boureau L, Cappellen D, Bedel A, Moreau-Gaudry F, Dulucq S, Dabernat S, Turcq B

CRISPR J. 2023 04;6(2):140-151

CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells.

Boutin J, Rosier J, Cappellen D, Prat F, Toutain J, Pennamen P, Bouron J, Rooryck C, Merlio JP, Lamrissi-Garcia I, Cullot G, Amintas S, Guyonnet-Duperat V, Ged C, Blouin JM, Richard E, Dabernat S, Moreau-Gaudry F, Bedel A

Nat Commun. 2021 08 13;12(1):4922

Mutation-Specific Guide RNA for Compound Heterozygous Porphyria On-target Scarless Correction by CRISPR/Cas9 in Stem Cells.

Prat F, Toutain J, Boutin J, Amintas S, Cullot G, Lalanne M, Lamrissi-Garcia I, Moranvillier I, Richard E, Blouin JM, Dabernat S, Moreau-Gaudry F, Bedel A

Stem Cell Reports. 2020 09 8;15(3):677-693

CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations.

Cullot G, Boutin J, Toutain J, Prat F, Pennamen P, Rooryck C, Teichmann M, Rousseau E, Lamrissi-Garcia I, Guyonnet-Duperat V, Bibeyran A, Lalanne M, Prouzet-Mauléon V, Turcq B, Ged C, Blouin JM, Richard E, Dabernat S, Moreau-Gaudry F, Bedel A

Nat Commun. 2019 03 8;10(1):1136

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