Fiche personne
Territoire
Bourgogne
Statut
Chercheur
Affiliation
Institut de Chimie Moléculaire de l'Université de Bourgogne (ICMUB) - UMR CNRS 6302 (ICMUB)
Équipes/plateformes
UMR 6302 - Equipe "Polyamines, Porphyrines, Développements et Applications (P2DA)"
Recherche
Mots clés : Chimie Biologie, Imagerie Moléculaire, Photophysique, Chimie de Synthèse
Expertises :
- Recherche:Chimie
Projets
Alternative Nucleic Acid Structures as Targets for Organic Molecules to Orchestrate Sustained genomic Instability and cellular Stress (ANASTOMOSIS)
2019 - Porteur du projet : Dr MONCHAUD David
Publications
Sex-linked helicases DDX3X and DDX3Y regulate G-quadruplex-associated stress in neurons.
Diaz Escarcega R, M J VK, Arizmendez A, Tan C, Urayama A, Marrelli SP, Morales R, Wefel JS, Zhang C, McCullough LD, Kim N, Monchaud D, Jung SY, Tsvetkov AS
Cell Death Dis. 2026 06 18;:
1950-2000: five decades of curiosity-driven discovery in alternative DNA structures.
Monchaud D
Nucleic Acids Res. 2026 04 23;54(8):
DNA damaging properties of G-quadruplex ligand QN-302 are potentiated by the DNA repair inhibitor Olaparib and mitigated by the molecular helicase PhpC.
Psalmon G, Pipier A, Barbotte M, Hudson RHE, Neidle S, Monchaud D
Genome Biol. 2026 04 11;:
Designing an ecofriendly catalyst for a sustainable use of water resources.
Qiu D, Zhang X, Tian F, Liu Y, He F, Yan X, Wei S, Mergny JL, Monchaud D, Zhang S, Ju H, Zhou J
Natl Sci Rev. 2026 01;13(2):nwaf447
Photoactivatable, Biomimetic Ligand photoMultiTASQ Traps DNA/RNA G‑Quadruplexes and Their Protein Binding Partners.
Raevens S, Danino YM, Desingle C, Rota Sperti F, Pirrotta M, Mazzucotelli L, Letissier L, Hornstein E, Cianferani S, Hernandez-Alba O, Valverde IE, Monchaud D
ACS Bio Med Chem Au. 2025 12 17;5(6):994-1006
Deciphering the intermolecular interactions between G-quadruplex (G4)-forming sequences.
Xia J, Zhou J, Zhuang X, Ju H, Monchaud D, Chaires JB, Šponer J, Mergny JL, Zhou J
Nucleic Acids Res. 2025 11 26;53(22):
Convergent Synthesis of Template-Assembled Synthetic G-Quartets (TASQs) Used as Biomimetic and Multivalent G-Quadruplex (G4) Ligands.
Raevens S, Desingle C, Pirrotta M, Sperti FR, Pieri A, Lejault P, Valverde IE, Monchaud D
Chemistry. 2025 11 20;:e03002
A Chimeric Photo-Controllable CRISPR/Cas12a System for Universal and Fast Diagnostics.
Yan X, Liu B, Zhou S, Fan Y, Wei S, Qiu D, Xiang H, Zhou J, Mergny JL, Monchaud D, Ju H, Zhou J
Anal Chem. 2025 10 29;:
Pharmacomodulation of G-quadruplexes in long non-coding RNAs dysregulated in colorectal cancer.
Sharma S, Mitteaux J, Pipier A, Pirrotta M, Penouilh MJ, Monchaud D, Datta B
BMC Biol. 2025 08 8;23(1):249
A Selective and Sensitive Method for Colistin Detection by G-Quadruplex Ligand Competition.
Wei S, Qiu D, Yan X, Liu B, Mergny JL, Monchaud D, Ju H, Zhou J
Anal Chem. 2025 07 31;:
Cellular modulation of a G-quadruplex structure found in the lung cancer-related microRNA-3196.
Alexandre D, Polido J, Miranda A, Hudson RHE, Monchaud D, Baptista PV, Cruz C
Int J Biol Macromol. 2025 06 15;:145263
RNA G-quadruplexes control mitochondria-localized mRNA translation and energy metabolism.
Dumas L, Shin S, Rigaud Q, Cargnello M, Hernández-Suárez B, Herviou P, Saint-Laurent N, Leduc M, Le Gall M, Monchaud D, Dassi E, Cammas A, Millevoi S
Nat Commun. 2025 04 7;16(1):3292
Ultra-Specific G-Quadruplex-Colistin Interaction for Efficient Transcriptome-Wide G4 Mapping.
Wei S, Zhang X, Feng Y, Tao S, Qiu D, Yan X, Li G, Guittat L, Zhang W, Monchaud D, Mergny JL, Ju H, Zhou J
J Am Chem Soc. 2025 03 6;:
Versatile Click Chemistry-based Approaches to Illuminate DNA and RNA G-Quadruplexes in Human Cells.
Pipier A, Monchaud D
Bio Protoc. 2025 02 5;15(3):e5209
FLUORESCENCE DETECTION OF DNA/RNA G-QUADRUPLEXES (G4s) BY TWICE-AS-SMART LIGANDS.
Ledvinka J, Rota Sperti F, Paragi G, Marc P, Chéron N, Valverde I, Menova P, Monchaud D
ChemMedChem. 2024 12 23;:e202400829
Protocol for cellular RNA G-quadruplex profiling using G4RP.v2.
Mitteaux J, Monchaud D
STAR Protoc. 2024 12 10;5(4):103480
Small molecule-based regulation of gene expression in human astrocytes switching on and off the G-quadruplex control systems.
M J VK, Mitteaux J, Wang Z, Wheeler E, Tandon N, Yun Jung S, Hudson RHE, Monchaud D, Tsvetkov AS
J Biol Chem. 2024 11 28;:108040
G-quadruplexes in an SVA retrotransposon cause aberrant TAF1 gene expression in X-linked dystonia parkinsonism.
Nicoletto G, Terreri M, Maurizio I, Ruggiero E, Cernilogar FM, Vaine CA, Cottini MV, Shcherbakova I, Penney EB, Gallina I, Monchaud D, Bragg DC, Schotta G, Richter SN
Nucleic Acids Res. 2024 09 17;:
Arginine-Modified Hemin Enhances G-Quadruplex DNAzyme Peroxidase Activity for High Sensitivity Detection.
Liu B, Wang T, Qiu D, Yan X, Liu Y, Mergny JL, Zhang X, Monchaud D, Ju H, Zhou J
Anal Chem. 2024 08 25;:
A Cost-Effective Hemin-Based Artificial Enzyme Allows for Practical Applications.
Qiu D, He F, Liu Y, Zhou Z, Yang Y, Long Z, Chen Q, Chen D, Wei S, Mao X, Zhang X, Mergny JL, Monchaud D, Ju H, Zhou J
Adv Sci (Weinh). 2024 06 25;:e2402237
i-Motif DNA: identification, formation, and cellular functions.
Tao S, Run Y, Monchaud D, Zhang W
Trends Genet. 2024 06 19;:
Structural Optimization of Azacryptands for Targeting Three-Way DNA Junctions.
Pipier A, Chetot T, Kalamatianou A, Martin N, Caroff M, Britton S, Chéron N, Trantírek L, Granzhan A, Monchaud D
Angew Chem Int Ed Engl. 2024 06 14;:e202409780
PhpC modulates G-quadruplex-RNA landscapes in human cells.
Mitteaux J, Raevens S, Wang Z, Pirrotta M, Valverde IE, Hudson RHE, Monchaud D
Chem Commun (Camb). 2023 12 12;:
UV-induced G4 DNA structures recruit ZRF1 which prevents UV-induced senescence.
De Magis A, Limmer M, Mudiyam V, Monchaud D, Juranek S, Paeschke K
Nat Commun. 2023 10 23;14(1):6705
Pirh2-dependent DNA damage in neurons induced by the G-quadruplex ligand pyridostatin.
Escarcega RD, Patil AA, Moruno-Manchon JF, Urayama A, Marrelli SP, Kim N, Monchaud D, McCullough LD, Tsvetkov AS
J Biol Chem. 2023 08 12;:105157
BLM helicase protein negatively regulates stress granule formation through unwinding RNA G-quadruplex structures.
Danino YM, Molitor L, Rosenbaum-Cohen T, Kaiser S, Cohen Y, Porat Z, Marmor-Kollet H, Katina C, Savidor A, Rotkopf R, Ben-Isaac E, Golani O, Levin Y, Monchaud D, Hickson ID, Hornstein E
Nucleic Acids Res. 2023 07 28;:
Development of a highly optimized procedure for the discovery of RNA G-quadruplexes by combining several strategies.
Turcotte MA, Bolduc F, Vannutelli A, Mitteaux J, Monchaud D, Perreault JP
Biochimie. 2023 07 19;:
The multivalent G-quadruplex (G4)-ligands MultiTASQs allow for versatile click chemistry-based investigations.
Rota Sperti F, Mitteaux J, Zell J, Pipier A, Valverde IE, Monchaud D
RSC Chem Biol. 2023 07 5;4(7):456-465
A Versatile G-quadruplex (G4)-coated Upconverted Metal-Organic Framework for Hypoxic Tumor Therapy.
Mao X, Zhang X, Chao Z, Qiu D, Wei S, Luo R, Chen D, Zhang Y, Chen Y, Yang Y, Monchaud D, Ju H, Mergny JL, Lei J, Zhou J
Adv Healthc Mater. 2023 07 4;:e2300561
Side-by-side comparison of G-quadruplex (G4) capture efficiency of the antibody BG4 versus the small-molecule ligands TASQs.
Feng Y, He Z, Luo Z, Sperti FR, Valverde IE, Zhang W, Monchaud D
iScience. 2023 06 16;26(6):106846
Chrysin-Induced Regression of Angiogenesis via an Induction of DNA Damage Response and Oxidative Stress in In Vitro and In Vivo Models of Melanoma.
Sassi A, Fredon M, Cotte AK, Fuselier C, Schneider C, Martiny L, Monchaud D, Chekir-Ghedira L, Aires V, Delmas D
Cells. 2023 06 6;12(12):
Chimeric Biocatalyst Combining Peptidic and Nucleic Acid Components Overcomes the Performance and Limitations of the Native Horseradish Peroxidase.
Zhang X, Qiu D, Chen J, Zhang Y, Wang J, Chen D, Liu Y, Cheng M, Monchaud D, Mergny JL, Ju H, Zhou J
J Am Chem Soc. 2023 02 16;:
Template-Assembled Synthetic G-Quartets (TASQs): multiTASQing Molecular Tools for Investigating DNA and RNA G-Quadruplex Biology.
Monchaud D
Acc Chem Res. 2023 01 20;:
Interactions of small molecules with DNA junctions.
McQuaid KT, Pipier A, Cardin CJ, Monchaud D
Nucleic Acids Res. 2022 11 16;:
rG4detector, a novel RNA G-quadruplex predictor, uncovers their impact on stress granule formation.
Turner M, Danino YM, Barshai M, Yacovzada NS, Cohen Y, Olender T, Rotkopf R, Monchaud D, Hornstein E, Orenstein Y
Nucleic Acids Res. 2022 11 9;:
Click-Chemistry-Based Biomimetic Ligands Efficiently Capture G-Quadruplexes and Help Localize Them at DNA Damage Sites in Human Cells.
Rota Sperti F, Dupouy B, Mitteaux J, Pipier A, Pirrotta M, Chéron N, Valverde IE, Monchaud D
JACS Au. 2022 07 25;2(7):1588-1595
Omics studies of DNA G-/C-quadruplexes in plants.
Li M, Tian R, Monchaud D, Zhang W
Trends Genet. 2022 07 16;:
Efficient Biocatalytic System for Biosensing by Combining Metal-Organic Framework (MOF)-Based Nanozymes and G-Quadruplex (G4)-DNAzymes.
Mao X, He F, Qiu D, Wei S, Luo R, Chen Y, Zhang X, Lei J, Monchaud D, Mergny JL, Ju H, Zhou J
Anal Chem. 2022 05 13;:
Targeting a G-quadruplex from let-7e pre-miRNA with small molecules and nucleolin.
Santos T, Miranda A, Imbert L, Monchaud D, Salgado GF, Cabrita EJ, Cruz C
J Pharm Biomed Anal. 2022 Apr 7;215:114757
Genome-wide characterization of i-motifs and their potential roles in the stability and evolution of transposable elements in rice.
Ma X, Feng Y, Yang Y, Li X, Shi Y, Tao S, Cheng X, Huang J, Wang XE, Chen C, Monchaud D, Zhang W
Nucleic Acids Res. 2022 Feb 21;:
Global mapping of RNA G-quadruplexes (G4-RNAs) using G4RP-seq.
Yang SY, Monchaud D, Wong JMY
Nat Protoc. 2022 Feb 9;:
Epigenomic Features of DNA G-Quadruplexes and Their Roles in Regulating Rice Gene Transcription.
Feng Y, Tao S, Zhang P, Sperti FR, Liu G, Cheng X, Zhang T, Yu H, Wang XE, Chen C, Monchaud D, Zhang W
Plant Physiol. 2021 Dec 6;:
Dual targeting of higher-order DNA structures by azacryptands induces DNA junction-mediated DNA damage in cancer cells.
Zell J, Duskova K, Chouh L, Bossaert M, Chéron N, Granzhan A, Britton S, Monchaud D
Nucleic Acids Res. 2021 Sep 22;:
G-quadruplexes mark alternative lengthening of telomeres.
Yang SY, Chang EYC, Lim J, Kwan HH, Monchaud D, Yip S, Stirling PC, Wong JMY
NAR Cancer. 2021 Sep;3(3):zcab031
Identifying G-Quadruplex-DNA-Disrupting Small Molecules.
Mitteaux J, Lejault P, Wojciechowski F, Joubert A, Boudon J, Desbois N, Gros CP, Hudson RHE, Boulé JB, Granzhan A, Monchaud D
J Am Chem Soc. 2021 Aug 4;:
Differential responses of neurons, astrocytes, and microglia to G-quadruplex stabilization.
Tabor N, Ngwa C, Mitteaux J, Meyer MD, Moruno-Manchon JF, Zhu L, Liu F, Monchaud D, McCullough LD, Tsvetkov AS
Aging (Albany NY). 2021 Jun 17;13:
Biomimetic, Smart, and Multivalent Ligands for G-Quadruplex Isolation and Bioorthogonal Imaging.
Sperti FR, Charbonnier T, Lejault P, Zell J, Bernhard C, Valverde IE, Monchaud D
ACS Chem Biol. 2021 Apr 29;:
How to untie G-quadruplex knots and why?
Lejault P, Mitteaux J, Sperti FR, Monchaud D
Cell Chem Biol. 2021 Feb 15;:
Insights into G-Quadruplex-Hemin Dynamics Using Atomistic Simulations: Implications for Reactivity and Folding.
Stadlbauer P, Islam B, Otyepka M, Chen J, Monchaud D, Zhou J, Mergny JL, Šponer J
J Chem Theory Comput. 2021 Feb 3;:
DNA folds threaten genetic stability and can be leveraged for chemotherapy.
Zell J, Rota Sperti F, Britton S, Monchaud D
RSC Chem Biol. 2021 Feb 1;2(1):47-76
Red Wine Extract Inhibits VEGF Secretion and Its Signaling Pathway in Retinal ARPE-19 Cells to Potentially Disrupt AMD.
Cornebise C, Courtaut F, Taillandier-Coindard M, Valls-Fonayet J, Richard T, Monchaud D, Aires V, Delmas D
Molecules. 2020 Nov 27;25(23):
The noncovalent dimerization of a G-quadruplex/hemin DNAzyme improves its biocatalytic properties.
Cheng Y, Cheng M, Hao J, Jia G, Monchaud D, Li C
Chem Sci. 2020 Aug 12;11(33):8846-8853
Regulation of autophagy by DNA G-quadruplexes.
Lejault P, Moruno-Manchon JF, Vemu SM, Honarpisheh P, Zhu L, Kim N, Urayama A, Monchaud D, McCullough LD, Tsvetkov AS
Autophagy. 2020 May 18;:
Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons.
Moruno-Manchon JF, Lejault P, Wang Y, McCauley B, Honarpisheh P, Morales Scheihing DA, Singh S, Dang W, Kim N, Urayama A, Zhu L, Monchaud D, McCullough LD, Tsvetkov AS
Elife. 2020 Feb 11;9:
An oxidatively damaged G-quadruplex/hemin DNAzyme.
Wang J, Cheng M, Chen J, Ju H, Monchaud D, Mergny JL, Zhou J
Chem. Commun. (Camb.). 2020 Jan 17;:
DNA junction ligands trigger DNA damage and are synthetic lethal with DNA repair inhibitors in cancer cells.
Duskova K, Lejault P, Benchimol É, Guillot R, Britton S, Granzhan A, Monchaud D
J. Am. Chem. Soc.. 2019 Dec 13;:
Improved performances of catalytic G-quadruplexes (G4-DNAzymes) via the chemical modifications of the DNA backbone to provide G-quadruplexes with double 3'-external G-quartets.
Virgilio A, Esposito V, Lejault P, Monchaud D, Galeone A
Int. J. Biol. Macromol.. 2019 Nov 17;:
Small-molecule affinity capture of DNA/RNA quadruplexes and their identification in vitro and in vivo through the G4RP protocol.
Renard I, Grandmougin M, Roux A, Yang SY, Lejault P, Pirrotta M, Wong JMY, Monchaud D
Nucleic Acids Res.. 2019 Apr 5;:
Identification of three-way DNA junction ligands through screening of chemical libraries and validation by complementary in vitro assays.
Duskova K, Lamarche J, Amor S, Caron C, Queyriaux N, Gaschard M, Penouilh MJ, De Robillard G, Delmas D, Devillers CH, Granzhan A, Teulade-Fichou MP, Chavarot-Kerlidou M, Therrien B, Britton S, Monchaud D
J. Med. Chem.. 2019 Apr 3;:
2nd PSL Chemical Biology Symposium (2019): At the Crossroads of Chemistry and Biology.
Lucchino M, Billet A, Versini A, Bavireddi H, Dasari BD, Debieu S, Colombeau L, Cañeque T, Wagner A, Masson G, Taran F, Karoyan P, Delepierre M, Gaillet C, Houdusse A, Britton S, Schmidt F, Florent JC, Belmont P, Monchaud D, Cossy J, Thomas C, Gautier A, Johannes L, Rodriguez R
Chembiochem. 2019 Feb 25;:
Transcriptome-wide identification of transient RNA G-quadruplexes in human cells.
Yang SY, Lejault P, Chevrier S, Boidot R, Robertson AG, Wong JMY, Monchaud D
Nat Commun. 2018 Nov 9;9(1):4730
TWJ-Screen: an isothermal screening assay to assess ligand/DNA junction interactions in vitro.
Guyon L, Pirrotta M, Duskova K, Granzhan A, Teulade-Fichou MP, Monchaud D
Nucleic Acids Res.. 2018 Feb 16;46(3):e16
A Thermophilic Tetramolecular G-Quadruplex/Hemin DNAzyme.
Guo Y, Chen J, Cheng M, Monchaud D, Zhou J, Ju H
Angew. Chem. Int. Ed. Engl.. 2017 Dec 22;56(52):16636-16640
The G-Quadruplex-Specific RNA Helicase DHX36 Regulates p53 Pre-mRNA 3'-End Processing Following UV-Induced DNA Damage.
Newman M, Sfaxi R, Saha A, Monchaud D, Teulade-Fichou MP, Vagner S
J. Mol. Biol.. 2017 Oct 27;429(21):3121-3131
Cellular Detection of G-Quadruplexes by Optical Imaging Methods.
Amor S, Yang SY, Wong JMY, Monchaud D
Curr Protoc Cell Biol. 2017 Sep 1;76:4.33.1-4.33.19
Real-time and quantitative fluorescent live-cell imaging with quadruplex-specific red-edge probe (G4-REP).
Yang SY, Amor S, Laguerre A, Wong JMY, Monchaud D
Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt B):1312-1320
Selective Luminescent Labeling of DNA and RNA Quadruplexes by π-Extended Ruthenium Light-Up Probes.
Saadallah D, Bellakhal M, Amor S, Lefebvre JF, Chavarot-Kerlidou M, Baussanne I, Moucheron C, Demeunynck M, Monchaud D
Chemistry. 2017 Apr 11;23(21):4967-4972
Computational understanding and experimental characterization of twice-as-smart quadruplex ligands as chemical sensors of bacterial nucleotide second messengers.
Zhou J, Roembke BT, Paragi G, Laguerre A, Sintim HO, Fonseca Guerra C, Monchaud D
Sci Rep. 2016 Sep 26;6:33888
Direct visualization of both DNA and RNA quadruplexes in human cells via an uncommon spectroscopic method.
Laguerre A, Wong JM, Monchaud D
Sci Rep. 2016 08 18;6:32141
Blending Quadruplexes and Bordeaux: A Grand Cru!
Yatsunyk LA, Monchaud D, Sen D
Cell Chem Biol. 2016 Mar 17;23(3):320-9
Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties.
Flack T, Constantin T, Penasse S, Dejeu J, Gennaro B, Jourdan M, Laguerre A, Pirrotta M, Monchaud D, Spinelli N, Defrancq E
Chemistry. 2016 Jan 26;22(5):1760-7
Visualization of RNA-Quadruplexes in Live Cells.
Laguerre A, Hukezalie K, Winckler P, Katranji F, Chanteloup G, Pirrotta M, Perrier-Cornet JM, Wong JM, Monchaud D
J. Am. Chem. Soc.. 2015 Jul 8;137(26):8521-5
Surface-promoted aggregation of amphiphilic quadruplex ligands drives their selectivity for alternative DNA structures.
Laguerre A, Chang Y, Pirrotta M, Desbois N, Gros CP, Lesniewska E, Monchaud D
Org. Biomol. Chem.. 2015 Jul 7;13(25):7034-9
Cationic azacryptands as selective three-way DNA junction binding agents.
Novotna J, Laguerre A, Granzhan A, Pirrotta M, Teulade-Fichou MP, Monchaud D
Org. Biomol. Chem.. 2015 Jan 7;13(1):215-22
Synthetic G-Quartets as Versatile Nanotools for the Luminescent Detection of G-Quadruplexes.
Laguerre A, Levillain M, Stefan L, Haudecoeur R, Katranji F, Pirrotta M, Monchaud D
Chimia (Aarau). 2015 ;69(9):530-6
A twice-as-smart synthetic G-quartet: PyroTASQ is both a smart quadruplex ligand and a smart fluorescent probe.
Laguerre A, Stefan L, Larrouy M, Genest D, Novotna J, Pirrotta M, Monchaud D
J. Am. Chem. Soc.. 2014 Sep 3;136(35):12406-14
Porphyrin-based design of bioinspired multitarget quadruplex ligands.
Laguerre A, Desbois N, Stefan L, Richard P, Gros CP, Monchaud D
ChemMedChem. 2014 Sep;9(9):2035-9
