DNA damaging properties of G-quadruplex ligand QN-302 are potentiated by the DNA repair inhibitor Olaparib and mitigated by the molecular helicase PhpC.

Fiche publication

Date publication

avril 2026

Journal

Genome biology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr MONCHAUD David

Tous les auteurs :
Psalmon G, Pipier A, Barbotte M, Hudson RHE, Neidle S, Monchaud D

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/41965726

Résumé

QN-302 is a tetra-substituted naphthalene diimide (NDI) designed to bind G-quadruplex (G4) DNA and is in a phase 1 clinical trial for pancreatic ductal adenocarcinoma (PDAC) and other solid tumors. The mechanistic basis of its anticancer activity remains to be fully understood.