Fiche publication
Date publication
novembre 2025
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr MONCHAUD David
,
Dr VALVERDE Ibai
Tous les auteurs :
Raevens S, Desingle C, Pirrotta M, Sperti FR, Pieri A, Lejault P, Valverde IE, Monchaud D
Lien Pubmed
Résumé
Precise insights into the biology of DNA and RNA G-quadruplexes (G4s) were obtained thanks to the use of ever more versatile G4-interacting molecules (or G4 ligands), which bear additional moieties making them functionalizable in situ (i.e., while in interaction with cellular G4s) thanks to bioorthogonal chemistry. We recently reported on a series of biomimetic G4 ligands known as TASQs (for template-assembled synthetic G-quartets) whose multifunctionality was exploited to visualize (pre-targeted and in situ click imaging) and identify cellular G4s (G4omics and Chem-CLIP). We report herein on a novel synthetic strategy that makes multivalent TASQs readily accessible and opens brand new perspectives for the design of ever smarter molecular tools to unravel the quite complex G4 biology in a more accurate, straightforward, and simpler manner.
Mots clés
G‐quadruplexes, Synthesis design, TASQ, chemical biology, macrocycles, molecular tools, synthetic G‐quartet
Référence
Chemistry. 2025 11 20;:e03002
