Dr GONCALVES Victor

Fiche personne

Coordonnées

ICMUB
9 avenue Alain Savary
BP 47870
21078 DIJON Cedex

03 80 39 60 88

Territoire

Bourgogne

Statut

Enseignant-Chercheur

Recherche

Mots clés : bioconjugaison, imagerie, radiothérapie interne vectorisée

Thématique de recherche :

Nous développons des outils de bioconjugaison qui permettent la modification site-spécifique de biomolécules (anticorps, fragments d’anticorps, peptides..).

Ces outils sont mis à profit pour greffer sur des biovecteurs :

des chélateurs de radiométaux, pour la conception de radiopharmaceutiques pour l’imagerie nucléaire et la radiothérapie interne vectorisée,
des sondes fluorescentes pour l'assistance à la chirurgie par imagerie de fluorescence,
des cytotoxiques pour la conception d’antibody-drug conjugates.

Projets

Validation de LOXL2 comme cible pour le diagnostic de l'adénocarcinome canalaire pancréatique (LOXSTIC)

2024 - Porteur du projet : Dr GONCALVES Victor - Partenaire : Pr COCHET Alexandre , Dr BELLAYE Pierre-Simon

Diagnostic du cancer par imagerie proche-infrarouge des tumeurs HSP70-positives (IMAGE-HSP70)

2016 - Porteur du projet : Dr GONCALVES Victor - Partenaire : Dr GARRIDO Carmen , Dr COLLIN Bertrand

Publications

Unexpected Reactivity of 1,3,4-Thiadiazole-N-oxides with Strained Alkynes Enables Enhanced Antibody Loading.

Bonnefoy Z, Da Silva Morais M, Penouilh MJ, Claron M, Moreau M, Rousselin Y, Fleurat-Lessard P, Bellaye PS, Racoeur C, Paul C, Denat F, Goncalves V

J Am Chem Soc. 2026 08 19;148(32):34615-34625

More Than a Glow: How Cyanine Dyes Shape Tracer Pharmacokinetics.

Saliën J, Romieu A, Denat F, Goncalves V, Hernot S

Angew Chem Int Ed Engl. 2026 07 24;:e9479227

Chelator Conjugation Chemistry Matters: Squaramide Linker Enhances Tumor Contrast in Ga-labeled Anti-CEA Nanobody Tracer.

Saliën J, Floru S, Van Hove M, De Pauw T, Vizier R, Claron M, Bridoux J, Goncalves V, Denat F, Hernot S

ACS Omega. 2026 04 7;11(13):20451-20460

Supramolecular Chemistry Enables Radiolabeling of Proteins under Mild Conditions.

Vizier R, Boswinkel M, Moreau M, Faivre J, Carrierre M, Cheveau M, Poty S, Denat F, van Lith SAM, Goncalves V

Mol Pharm. 2025 10 13;:

Collagen-targeted PET imaging for progressive experimental lung fibrosis quantification and monitoring of efficacy of anti-fibrotic therapies.

Dias AMM, Burgy O, Moreau M, Goncalves V, Pommerolle L, Douhard R, Courteau A, Helbling A, Guillemin M, Simonet J, Oudot A, Garrido C, Bonniaud P, Goirand F, Collin B, Bellaye PS

Theranostics. 2025 01 13;15(6):2092-2103

Preoperative PET imaging and fluorescence-guided surgery of human glioblastoma using dual-labeled antibody targeting ET receptors in a preclinical mouse model: A theranostic approach.

Hautiere M, Vivier D, Dorval P, Pineau D, Kereselidze D, Denis C, Herbet A, Costa N, Bernhard C, Goncalves V, Selingue E, Larrat B, Dancer PA, Hugnot JP, Boquet D, Truillet C, Denat F

Theranostics. 2024 09 30;14(16):6268-6280

CD206 macrophages are relevant non-invasive imaging biomarkers and therapeutic targets in experimental lung fibrosis.

Pommerolle L, Beltramo G, Biziorek L, Truchi M, Dias AMM, Dondaine L, Tanguy J, Pernet N, Goncalves V, Bouchard A, Monterrat M, Savary G, Pottier N, Ask K, Kolb MRJ, Mari B, Garrido C, Collin B, Bonniaud P, Burgy O, Goirand F, Bellaye PS

Thorax. 2024 07 20;:

Moving Beyond Isothiocyanates: A Look at the Stability of Conjugation Links Toward Radiolysis in Zr-Labeled Immunoconjugates.

Vizier R, Adumeau P, Moreau M, Goncalves V, Denat F

Bioconjug Chem. 2024 04 24;:

Synthesis and Preclinical Fluorescence Imaging of Dually Functionalized Antibody Conjugates Targeting Endothelin Receptor-Positive Tumors.

Vivier D, Hautière M, Pineau D, Dancer PA, Herbet A, Hugnot JP, Bernhard C, Goncalves V, Truillet C, Boquet D, Denat F

Bioconjug Chem. 2023 11 6;:

SPECT Imaging of Lysyl Oxidase-like 2 in a Model of Idiopathic Pulmonary Fibrosis.

Vizier R, Garnier AR, Dias A, Moreau M, Claron M, Collin B, Denat F, Bellaye PS, Goncalves V

Mol Pharm. 2023 06 12;:

ImmunoPET imaging-based pharmacokinetic profiles of an antibody and its Fab targeting endothelin A receptors on glioblastoma stem cells in a preclinical orthotopic model.

Hautiere M, Vivier D, Pineau D, Denis C, Kereselidze D, Herbet A, Costa N, Goncalves V, Selingue E, Larrat B, Hugnot JP, Denat F, Boquet D, Truillet C

Eur J Nucl Med Mol Imaging. 2023 06 7;:

Modular One-Pot Strategy for the Synthesis of Heterobivalent Tracers.

Bailly T, Bodin S, Goncalves V, Denat F, Morgat C, Prignon A, Valverde IE

ACS Med Chem Lett. 2023 05 11;14(5):636-644

Site-Specific, Platform-Based Conjugation Strategy for the Synthesis of Dual-Labeled Immunoconjugates for Bimodal PET/NIRF Imaging of HER2-Positive Tumors.

Adumeau P, Raavé R, Boswinkel M, Heskamp S, Wessels HJCT, van Gool AJ, Moreau M, Bernhard C, Da Costa L, Goncalves V, Denat F

Bioconjug Chem. 2022 Mar 1;:

Positron Emission Tomography Imaging of Neurotensin Receptor-Positive Tumors with Ga-Labeled Antagonists: The Chelate Makes the Difference Again.

Renard E, Moreau M, Bellaye PS, Guillemin M, Collin B, Prignon A, Denat F, Goncalves V

J Med Chem. 2021 Jun 9;:

Site-Specific Dual-Labeling of a VHH with a Chelator and a Photosensitizer for Nuclear Imaging and Targeted Photodynamic Therapy of EGFR-Positive Tumors.

Renard E, Collado Camps E, Canovas C, Kip A, Gotthardt M, Rijpkema M, Denat F, Goncalves V, van Lith SAM

Cancers (Basel). 2021 Jan 23;13(3):

Additional information on "Direct comparison of the in vitro and in vivo stability of DFO, DFO* and DFOcyclo* for Zr-immunoPET".

Raavé R, Sandker G, Adumeau P, Jacobsen CB, Mangin F, Meyer M, Moreau M, Bernhard C, Da Costa L, Dubois A, Goncalves V, Gustafsson M, Rijpkema M, Boerman O, Chambron JC, Heskamp S, Denat F

Eur J Nucl Med Mol Imaging. 2020 02;47(2):505-506

Design of Bimodal Ligands of Neurotensin Receptor 1 for PET Imaging and Fluorescence-Guided Surgery of Pancreatic Cancer.

Renard E, Dancer PA, Portal C, Denat F, Prignon A, Goncalves V

J. Med. Chem.. 2019 Dec 19;:

Synthesis and evaluation of zirconium-89 labelled and long-lived GLP-1 receptor agonists for PET imaging.

Jacobsen CB, Raavé R, Pedersen MØ, Adumeau P, Moreau M, Valverde IE, Bjørnsdottir I, Kristensen JB, Grove MF, Raun K, McGuire J, Goncalves V, Heskamp S, Denat F, Gustafsson M

Nucl. Med. Biol.. 2019 Dec 4;82-83:49-56

Direct comparison of the in vitro and in vivo stability of DFO, DFO* and DFOcyclo* for Zr-immunoPET.

Raavé R, Sandker G, Adumeau P, Jacobsen CB, Mangin F, Meyer M, Moreau M, Bernhard C, Da Costa L, Dubois A, Goncalves V, Gustafsson M, Rijpkema M, Boerman O, Chambron JC, Heskamp S, Denat F

Eur. J. Nucl. Med. Mol. Imaging. 2019 Jun 3;: