Dr COLLIN Bertrand

Fiche personne

Coordonnées

Centre Georges-François Leclerc
1 rue du Professeur Marion
BP 77980
21079 DIJON

03 80 73 80 71

Territoire

Bourgogne

Statut

Enseignant-Chercheur

Affiliation

Centre Georges-François Leclerc (CGFL)

Université Bourgogne Europe (UBE)

Institut de Chimie Moléculaire de l'Université de Bourgogne (ICMUB) - UMR CNRS 6302 (ICMUB)

Unité mixte de service 58 Biologie Santé Dijon - BioSanD (US58 BioSanD)

Équipes/plateformes

Département de Médecine Nucléaire

UMR 6302 - Equipe "Polyamines, Porphyrines, Développements et Applications (P2DA)"

Equipe "Radiopharmaceutiques, imagerie, théranostiques et multimodalité (RITM)"

Plateforme d'imagerie et de radiothérapie préclinique IMATHERa

Recherche

Mots clés : Bioconjugaison et peptides, Chimie Biologie, Imagerie Moléculaire

Projets

Nanostructures à base d’or pour la radiothérapie interne (IRRO)

2024 - Porteur du projet : Pr ROUX Stéphane - Partenaire : Pr DENAT Franck , Dr COLLIN Bertrand

Imagerie par Luminescence Cherenkov de modèles de cancer du sein et Photothérapie Dynamique Cherenkov (CLI)

2018 - Porteur du projet : Dr DECREAU Richard - Partenaire : Dr COLLIN Bertrand , Pr COCHET Alexandre

Diagnostic du cancer par imagerie proche-infrarouge des tumeurs HSP70-positives (IMAGE-HSP70)

2016 - Porteur du projet : Dr GONCALVES Victor - Partenaire : Dr GARRIDO Carmen , Dr COLLIN Bertrand

Publications

SPECT/NIR Fluorescence Bimodal Use of Aza-BODIPY Probe Coupled with Cetuximab for Detection of Cancer: Proof of Concept on a Preclinical Head and Neck Squamous Cell Carcinoma Model.

Fabre C, Godard A, Privat M, Moreau M, Dalonneau F, Sickinger A, Maury O, Bellaye PS, Collin B, Busser B, Righini CA, Goze C, Bodio E, Sancey L

J Med Chem. 2026 04 21;:

SPECT as a translational non-invasive method to assess occupancy of the tissue transglutaminase-2 by zampilimab in the mouse lung.

Bellaye PS, Ferrini E, Claron M, Dias A, Bonfini C, Villetti G, Capelli AM, Johnson T, Collin B, Stellari FF

Respir Res. 2026 02 12;:

Versatile Bifunctional PYTA Derivatives for Ac Radiolabeling: A Comparison to Gold Standards.

Cheveau M, Moreau M, Grohmann A, Robert S, Cochet A, Collin B, Boschetti F, Poty S, Denat F

J Nucl Med. 2025 07 10;:

Collagen-targeted PET imaging for progressive experimental lung fibrosis quantification and monitoring of efficacy of anti-fibrotic therapies.

Dias AMM, Burgy O, Moreau M, Goncalves V, Pommerolle L, Douhard R, Courteau A, Helbling A, Guillemin M, Simonet J, Oudot A, Garrido C, Bonniaud P, Goirand F, Collin B, Bellaye PS

Theranostics. 2025 01 13;15(6):2092-2103

CD40 agonist on patient-derived xenograft mice for the treatment of B-cell acute lymphoblastic leukemia.

Bellaye PS, Georgievski A, Ballerini P, Bouslama B, Richard C, Boidot R, Chevreux G, Legros V, Guy J, Racine J, Collin B, Garrido C, Quéré R

Clin Cancer Res. 2024 11 14;:

Targeted radionuclide therapy against GARP expressing T regulatory cells after tumour priming with external beam radiotherapy in a murine syngeneic model.

Bellaye PS, Dias AM, Vrigneaud JM, Bouchard A, Moreau M, Petitot C, Bernhard C, Claron M, Froidurot L, Morgand V, Guillemin M, Monterrat M, Mirjolet C, Garrido C, Kohli E, Collin B

Heliyon. 2024 10 30;10(20):e39543

Postnatally overfed mice display cardiac function alteration following myocardial infarction.

Josse M, Rigal E, Rosenblatt-Velin N, Collin B, Dogon G, Rochette L, Zeller M, Vergely C

Biochim Biophys Acta Mol Basis Dis. 2024 09 18;:167516

CD206 macrophages are relevant non-invasive imaging biomarkers and therapeutic targets in experimental lung fibrosis.

Pommerolle L, Beltramo G, Biziorek L, Truchi M, Dias AMM, Dondaine L, Tanguy J, Pernet N, Goncalves V, Bouchard A, Monterrat M, Savary G, Pottier N, Ask K, Kolb MRJ, Mari B, Garrido C, Collin B, Bonniaud P, Burgy O, Goirand F, Bellaye PS

Thorax. 2024 07 20;:

Valrubicin-loaded immunoliposomes for specific vesicle-mediated cell death in the treatment of hematological cancers.

Georgievski A, Bellaye PS, Tournier B, Choubley H, Pais de Barros JP, Herbst M, Béduneau A, Callier P, Collin B, Végran F, Ballerini P, Garrido C, Quéré R

Cell Death Dis. 2024 05 11;15(5):328

Development of an Immuno-SPECT/Fluorescent Bimodal Tracer Targeting Human or Murine PD-L1 on Preclinical Models.

Privat M, Massot A, Hermetet F, Al Sabea H, Racoeur C, Mabrouk N, Cordonnier M, Moreau M, Collin B, Bettaieb A, Denat F, Bodio E, Bellaye PS, Goze C, Paul C

J Med Chem. 2024 01 25;:

Cherenkov Radiation induced photodynamic therapy - repurposing older photosensitizers, and radionuclides.

Lioret V, Bellaye PS, Bernhard Y, Moreau M, Guillemin M, Drouet C, Collin B, Decréau RA

Photodiagnosis Photodyn Ther. 2023 09 30;:103816

SPECT Imaging of Lysyl Oxidase-like 2 in a Model of Idiopathic Pulmonary Fibrosis.

Vizier R, Garnier AR, Dias A, Moreau M, Claron M, Collin B, Denat F, Bellaye PS, Goncalves V

Mol Pharm. 2023 06 12;:

Oleanolic Acid Glycosides from and : Structural Analysis and Cytotoxicity.

Nazaryan S, Bruguière A, Hovhannisyan N, Miyamoto T, Dias AMM, Bellaye PS, Collin B, Briand L, Mitaine-Offer AC

Molecules. 2023 05 25;28(11):

First Comparison Study of the and Properties of a Randomly and Site-Specifically Conjugated SPECT/NIRF Monomolecular Multimodal Imaging Probe (MOMIP) Based on an aza-BODIPY Fluorophore.

Privat M, Bellaye PS, Chazeau E, Racoeur C, Adumeau P, Vivier D, Bernhard C, Moreau M, Collin B, Bettaieb A, Denat F, Bodio E, Paul C, Goze C

Bioconjug Chem. 2023 03 27;:

IL-1RAP, a Key Therapeutic Target in Cancer.

Frenay J, Bellaye PS, Oudot A, Helbling A, Petitot C, Ferrand C, Collin B, Dias AMM

Int J Mol Sci. 2022 11 29;23(23):

Superparamagnetic Iron Oxide Nanoparticles for Immunotherapy of Cancers through Macrophages and Magnetic Hyperthermia.

Dias AMM, Courteau A, Bellaye PS, Kohli E, Oudot A, Doulain PE, Petitot C, Walker PM, Decréau R, Collin B

Pharmaceutics. 2022 11 5;14(11):

Development of Anti-LRRC15 Small Fragments for Imaging Purposes Using a Phage-Display ScFv Approach.

Baurand PE, Balland J, Reynas C, Ramseyer M, Vivier D, Bellaye PS, Collin B, Paul C, Denat F, Asgarov K, Pallandre JR, Ringenbach L

Int J Mol Sci. 2022 10 21;23(20):

Oleanane-type glycosides isolated from the trunk barks of the central African tree Millettia laurentii.

Pertuit D, Mitaine-Offer AC, Miyamoto T, Tanaka C, Delaude C, Bellaye PS, Collin B, Lacaille-Dubois MA

Fitoterapia. 2022 Apr 12;:105193

Measurement of hypoxia in the lung in idiopathic pulmonary fibrosis: a matter of control.

Bellaye PS, Beltramo G, Burgy O, Collin B, Cochet A, Bonniaud P

Eur Respir J. 2022 Jan 27;:

MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells.

Limagne E, Nuttin L, Thibaudin M, Jacquin E, Aucagne R, Bon M, Revy S, Barnestein R, Ballot E, Truntzer C, Derangère V, Fumet JD, Latour C, Rébé C, Bellaye PS, Kaderbhaï CG, Spill A, Collin B, Callanan MB, Lagrange A, Favier L, Coudert B, Arnould L, Ladoire S, Routy B, Joubert P, Ghiringhelli F

Cancer Cell. 2022 Jan 17;:

The GRP94 Inhibitor PU-WS13 Decreases M2-like Macrophages in Murine TNBC Tumors: A Pharmaco-Imaging Study with Tc-Tilmanocept SPECT.

Bouchard A, Sikner H, Baverel V, Garnier AR, Monterrat M, Moreau M, Limagne E, Garrido C, Kohli E, Collin B, Bellaye PS

Cells. 2021 12 2;10(12):

Steroidal glycosides from the Vietnamese cultivar Cordyline fruticosa "Fairchild red".

Nguyen DH, Mitaine-Offer AC, Miyamoto T, Tanaka C, Bellaye PS, Collin B, Chambin O, Lacaille-Dubois MA

Phytochemistry. 2021 Oct 5;192:112966

[I]MIBG is a better early marker of anthracycline cardiotoxicity than [F]FDG: a preclinical SPECT/CT and simultaneous PET/MR study.

Oudot A, Courteau A, Guillemin M, Vrigneaud JM, Walker PM, Brunotte F, Cochet A, Collin B

EJNMMI Res. 2021 Sep 20;11(1):92

GARP: A Key Target to Evaluate Tumor Immunosuppressive Microenvironment.

Bouchard A, Collin B, Garrido C, Bellaye PS, Kohli E

Biology (Basel). 2021 Aug 27;10(9):

Development of an Easily Bioconjugatable Water-Soluble Single-Photon Emission-Computed Tomography/Optical Imaging Bimodal Imaging Probe Based on the aza-BODIPY Fluorophore.

Privat M, Bellaye PS, Lescure R, Massot A, Baffroy O, Moreau M, Racoeur C, Marcion G, Denat F, Bettaieb A, Collin B, Bodio E, Paul C, Goze C

J Med Chem. 2021 Aug 2;:

Positron Emission Tomography Imaging of Neurotensin Receptor-Positive Tumors with Ga-Labeled Antagonists: The Chelate Makes the Difference Again.

Renard E, Moreau M, Bellaye PS, Guillemin M, Collin B, Prignon A, Denat F, Goncalves V

J Med Chem. 2021 Jun 9;:

Near-infrared emitting fluorescent homobimetallic gold(I) complexes displaying promising in vitro and in vivo therapeutic properties.

Lescure R, Privat M, Pliquett J, Massot A, Baffroy O, Busser B, Bellaye PS, Collin B, Denat F, Bettaïeb A, Sancey L, Paul C, Goze C, Bodio E

Eur J Med Chem. 2021 Apr 19;220:113483

[F]FMISO PET/CT imaging of hypoxia as a non-invasive biomarker of disease progression and therapy efficacy in a preclinical model of pulmonary fibrosis: comparison with the [F]FDG PET/CT approach.

Tanguy J, Goirand F, Bouchard A, Frenay J, Moreau M, Mothes C, Oudot A, Helbling A, Guillemin M, Bonniaud P, Cochet A, Collin B, Bellaye PS

Eur J Nucl Med Mol Imaging. 2021 Feb 13;:

Nanofitins targeting heat shock protein 110: an innovative immunotherapeutic modality in cancer.

Marcion G, Hermetet F, Neiers F, Uyanik B, Dondaine L, Dias AMM, Da Costa L, Moreau M, Bellaye PS, Collin B, Gobbo J, Briand L, Seigneuric R, Kitten O, Cinier M, Garrido C

Int J Cancer. 2021 Jan 27;:

The HSP GRP94 interacts with macrophage intracellular complement C3 and impacts M2 profile during ER stress.

Chaumonnot K, Masson S, Sikner H, Bouchard A, Baverel V, Bellaye PS, Collin B, Garrido C, Kohli E

Cell Death Dis. 2021 Jan 22;12(1):114

Lipoproteins LDL versus HDL as nanocarriers to target either cancer cells or macrophages.

Hadi T, Ramseyer C, Gautier T, Bellaye PS, Lopez T, Schmitt A, Sarah F, Yesylevskyy S, Minervini T, Douhard R, Dondaine L, Proukhnitzky L, Messaoudi S, Wendremaire M, Moreau M, Neiers F, Collin B, Denat F, Lagrost L, Garrido C, Lirussi F

JCI Insight. 2020 Nov 24;:

Dual Cherenkov Radiation-induced Near-Infrared Luminescence Imaging and Photodynamic Therapy towards Tumor Resection.

Lioret V, Bellaye PS, Arnould C, Collin B, Decreau RA

J. Med. Chem.. 2020 Jul 24;:

Aza-BODIPY Platform: Toward an Efficient Water-Soluble Bimodal Imaging Probe for MRI and Near-Infrared Fluorescence.

Florès O, Pliquett J, Abad Galan L, Lescure R, Denat F, Maury O, Pallier A, Bellaye PS, Collin B, Même S, Bonnet CS, Bodio E, Goze C

Inorg Chem. 2020 Jan 7;:

Cleaved Caspase-3 transcriptionally regulates angiogenesis promoting chemotherapy resistance.

Bernard A, Chevrier S, Beltjens F, Dosset M, Viltard E, Lagrange A, Dérangère V, Oudot A, Ghiringhelli F, Collin B, Apetoh L, Feron O, Chen S, Arnould L, Végran F, Boidot R

Cancer Res.. 2019 Oct 14;:

Superparamagnetic Nanoparticle Delivery to the Cochlea Through Round Window by External Magnetic Field: Feasibility and Toxicity.

Leterme G, Guigou C, Oudot A, Collin B, Boudon J, Millot N, Geissler A, Belharet K, Bozorg Grayeli A

Surg Innov. 2019 Sep 3;:1553350619867217

Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging.

Thakare V, Tran VL, Natuzzi M, Thomas E, Moreau M, Romieu A, Collin B, Courteau A, Vrigneaud JM, Louis C, Roux S, Boschetti F, Tillement O, Lux F, Denat F

RSC Adv. 2019 Aug 8;9(43):24811-24815

Cytotoxic glycosides from the roots of Weigela x "Bristol Ruby".

Nguyen DH, Mitaine-Offer AC, Maroso S, Papini AM, Paululat T, Bellaye PS, Collin B, Chambin O, Lacaille-Dubois MA

Fitoterapia. 2019 Jun 13;:104242

Modular assembly of multimodal imaging agents through an inverse electron demand Diels-Alder reaction.

Canovas C, Moreau M, Vrigneaud JM, Bellaye PS, Collin B, Denat F, Goncalves V

Bioconjug. Chem.. 2019 Feb 11;:

A promising family of fluorescent water-soluble aza-BODIPY dyes for in vivo molecular imaging.

Pliquett J, Dubois A, Racoeur C, Mabrouk N, Amor S, Lescure R, Bettaieb A, Collin B, Bernhard C, Denat F, Bellaye PS, Paul C, Bodio E, Goze C

Bioconjug. Chem.. 2019 Jan 7;:

Cherenkov luminescence imaging is a fast and relevant preclinical tool to assess tumour hypoxia in vivo.

Desvaux E, Courteau A, Bellaye PS, Guillemin M, Drouet C, Walker P, Collin B, Decréau RA

EJNMMI Res. 2018 Dec 20;8(1):111

Radiolabeled F(ab')-cetuximab for theranostic purposes in colorectal and skin tumor-bearing mice models.

Bellaye PS, Moreau M, Raguin O, Oudot A, Bernhard C, Vrigneaud JM, Dumont L, Vandroux D, Denat F, Cochet A, Brunotte F, Collin B

Clin Transl Oncol. 2018 May 17;:

Nuclear Imaging Study of the Pharmacodynamic Effects of Debio 1143, an Antagonist of Multiple Inhibitor of Apoptosis Proteins (IAPs), in a Triple-Negative Breast Cancer Model.

Bellaye PS, Oudot A, Vrigneaud JM, Raguin O, Bichat F, Vaslin A, Maby-El Hajjami H, Zanna C, Vuagniaux G, Fumoleau P, Denat F, Brunotte F, Collin B

Contrast Media Mol Imaging. 2018 ;2018:8494031

MANOTA: a promising bifunctional chelating agent for copper-64 immunoPET.

Moreau M, Poty S, Vrigneaud JM, Walker P, Guillemin M, Raguin O, Oudot A, Bernhard C, Goze C, Boschetti F, Collin B, Brunotte F, Denat F

Dalton Trans. 2017 Sep;:

Redshifted Cherenkov Radiation for in vivo Imaging: Coupling Cherenkov Radiation Energy Transfer to multiple Förster Resonance Energy Transfers.

Bernhard Y, Collin B, Decréau RA

Sci Rep. 2017 Mar;7:45063

Docetaxel-titanate nanotubes enhance radiosensitivity in an androgen-independent prostate cancer model.

Mirjolet C, Boudon J, Loiseau A, Chevrier S, Boidot R, Oudot A, Collin B, Martin E, Joy PA, Millot N, Créhange G

Int J Nanomedicine. 2017 ;12:6357-6364

Near-Infrared-Emitting BODIPY-trisDOTA(111) In as a Monomolecular Multifunctional Imaging Probe: From Synthesis to In Vivo Investigations.

Maindron N, Ipuy M, Bernhard C, Lhenry D, Moreau M, Carme S, Oudot A, Collin B, Vrigneaud JM, Provent P, Brunotte F, Denat F, Goze C

Chemistry. 2016 Aug;22(36):12670-4

Minor changes in the macrocyclic ligands but major consequences on the efficiency of gold nanoparticles designed for radiosensitization.

Laurent G, Bernhard C, Dufort S, Jiménez Sánchez G, Bazzi R, Boschetti F, Moreau M, Vu TH, Collin B, Oudot A, Herath N, Requardt H, Laurent S, Vander Elst L, Muller R, Dutreix M, Meyer M, Brunotte F, Perriat P, Lux F, Tillement O, Le Duc G, Denat F, Roux S

Nanoscale. 2016 Jun;8(23):12054-65