Fiche publication
Date publication
juillet 2026
Journal
Angewandte Chemie (International ed. in English)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DENAT Franck
,
Dr GONCALVES Victor
Tous les auteurs :
Saliën J, Romieu A, Denat F, Goncalves V, Hernot S
Lien Pubmed
Résumé
Fluorescence molecular imaging stands as a crucial method for tracking physiological or pathological biomarkers within living organisms. In clinical practice, this technology is increasingly applied to assist physicians in decision-making during interventional or surgical procedures. To develop imaging tracers, targeting molecules are covalently labeled with fluorescent organic dyes. Yet, it is often overlooked that such modifications to the molecule can influence and even alter its pharmacokinetics and distribution within the body. This review aims to provide an overview of the advancements in fluorophores commonly used in translational and clinical fluorescence molecular imaging, with a specific focus on long-wavelength cyanine dyes. Additionally, we will illustrate how the fluorophore's structure and labeling parameters influence the in vivo behavior of molecules, underscoring the importance of considering these aspects when designing fluorescent tracers.
Mots clés
cyanines, fluorescence‐guided surgery, fluorescent probes, imaging agents, targeted tracer
Référence
Angew Chem Int Ed Engl. 2026 07 24;:e9479227
