Fiche publication
Date publication
septembre 2014
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DENAT Franck
,
Dr GONCALVES Victor
Tous les auteurs :
Brizet B, Goncalves V, Bernhard C, Harvey PD, Denat F, Goze C
Lien Pubmed
Résumé
Several new boron dipyrromethene/N,N-dimethylaminopyridine (BODIPY-DMAP) assemblies were synthesized as precursors for bimodal imaging probes (optical imaging, OI/positron emission tomography, PET). The photophysical properties of the new compounds were also studied. The first proof-of-concept was obtained with the preparation of several new BODIPY-labeled bombesins and evaluation of the affinity for bombesin receptors by using a competition binding assay. Fluorination reactions were investigated on DMAP-BODIPY precursors as well as on DMAP-BODIPY-labeled bombesins. Chemical modifications on the BODIPY core were also performed to obtain luminescent dyes emitting in the therapeutic window (650-900 nm), suitable for in vivo imaging, making these compounds promising precursors for PET/optical dual-modality imaging agents.
Mots clés
Alkynes, chemical synthesis, Bombesin, analysis, Boron Compounds, chemical synthesis, Click Chemistry, Halogenation, Luminescent Agents, chemical synthesis, Optical Imaging, methods, Positron-Emission Tomography, methods, Pyridines, chemical synthesis
Référence
Chemistry. 2014 Sep;20(40):12933-44
