Kalfeist L, Ledys F, Petit S, Poirrier C, Kada Mohammed S, Galland L, Derangère V, Ilie A, Rageot D, Aucagne R, Bellaye PS, Truntzer C, Thibaudin M, Rialland M, Ghiringhelli F, Limagne E, Ladoire S

J Clin Invest. 2025 07 1;135(13):

Inhibition of LXR Signaling in Human Foam Cells Impairs Macrophage-to-Endothelial Cell Cross Talk and Promotes Endothelial Cell Inflammation.

Leleu D, Pilot T, Mangin L, Van Dongen K, Proukhnitzky L, Denimal D, Samson M, Laubriet A, Steinmetz E, Rialland M, Pierre L, Groetz E, Pais de Barros JP, Gautier T, Thomas C, Masson D

Arterioscler Thromb Vasc Biol. 2025 04 10;:

Impaired unsaturated fatty acid elongation alters mitochondrial function and accelerates metabolic dysfunction-associated steatohepatitis progression.

Vouilloz A, Bourgeois T, Diedisheim M, Pilot T, Jalil A, Le Guern N, Bergas V, Rohmer N, Castelli F, Leleu D, Varin A, de Barros JP, Degrace P, Rialland M, Blériot C, Venteclef N, Thomas C, Masson D

Metabolism. 2024 10 23;:156051

Downregulation of Elovl5 promotes breast cancer metastasis through a lipid-droplet accumulation-mediated induction of TGF-β receptors.

Kieu TL, Pierre L, Derangère V, Perrey S, Truntzer C, Jalil A, Causse S, Groetz E, Dumont A, Guyard L, Arnould L, de Barros JP, Apetoh L, Rébé C, Limagne E, Jourdan T, Demizieux L, Masson D, Thomas C, Ghiringhelli F, Rialland M

Cell Death Dis. 2022 09 2;13(9):758

NLRP3 inflammasome-mediated cytokine production and pyroptosis cell death in breast cancer.

Faria SS, Costantini S, de Lima VCC, de Andrade VP, Rialland M, Cedric R, Budillon A, Magalhães KG

J Biomed Sci. 2021 Apr 12;28(1):26

Inhibition of mitophagy drives macrophage activation and anti-bacterial defense during sepsis.

Patoli D, Mignotte F, Deckert V, Dusuel A, Dumont A, Rieu A, Jalil A, Van Dongen K, Bourgeois T, Gautier T, Magnani C, Le Guern N, Mandard S, Bastin J, Djouadi F, Schaeffer C, Guillaumot N, Narce M, Nguyen M, Guy J, Dargent A, Quenot JP, Rialland M, Masson D, Auwerx J, Lagrost L, Thomas C

J. Clin. Invest.. 2020 Aug 6;:

Docosahexaenoic acid inhibits both NLRP3 inflammasome assembly and JNK-mediated mature IL-1β secretion in 5-fluorouracil-treated MDSC: implication in cancer treatment.

Dumont A, de Rosny C, Kieu TL, Perrey S, Berger H, Fluckiger A, Muller T, Pais de Barros JP, Pichon L, Hichami A, Thomas C, Rébé C, Ghiringhelli F, Rialland M

Cell Death Dis. 2019 Jun 19;10(7):485

Nlrp3 Gene Expression in Circulating Leukocytes Declines During Healthy Aging.

Connat JL, Dumont A, Rialland M, Faivre B, Sorci G

J. Gerontol. A Biol. Sci. Med. Sci.. 2018 Feb 3;:

Protective effects of polyphenol-rich infusions from carob (Ceratonia siliqua) leaves and cladodes of Opuntia ficus-indica against inflammation associated with diet-induced obesity and DSS-induced colitis in Swiss mice.

Aboura I, Nani A, Belarbi M, Murtaza B, Fluckiger A, Dumont A, Benammar C, Tounsi MS, Ghiringhelli F, Rialland M, Khan NA, Hichami A

Biomed. Pharmacother.. 2017 Dec;96:1022-1035

Correction: Phenolic extract from oleaster (Olea europaea var. Sylvestris) leaves reduces colon cancer growth and induces caspase-dependent apoptosis in colon cancer cells via the mitochondrial apoptotic pathway.

Zeriouh W, Nani A, Belarbi M, Dumont A, de Rosny C, Aboura I, Ghanemi FZ, Murtaza B, Patoli D, Thomas C, Apetoh L, Rébé C, Delmas D, Khan NA, Ghiringhelli F, Rialland M, Hichami A

PLoS ONE. 2017 ;12(4):e0176574

Phenolic extract from oleaster (Olea europaea var. Sylvestris) leaves reduces colon cancer growth and induces caspase-dependent apoptosis in colon cancer cells via the mitochondrial apoptotic pathway.

Zeriouh W, Nani A, Belarbi M, Dumont A, de Rosny C, Aboura I, Ghanemi FZ, Murtaza B, Patoli D, Thomas C, Apetoh L, Rébé C, Delmas D, Akhtar Khan N, Ghiringhelli F, Rialland M, Hichami A

PLoS ONE. 2017 ;12(2):e0170823

Inhibition of colon cancer growth by docosahexaenoic acid involves autocrine production of TNFα.

Fluckiger A, Dumont A, Derangère V, Rébé C, de Rosny C, Causse S, Thomas C, Apetoh L, Hichami A, Ghiringhelli F, Rialland M

Oncogene. 2016 Sep;35(35):4611-22

Liver X receptor ligand cytotoxicity in colon cancer cells and not in normal colon epithelial cells depends on LXRbeta subcellular localization.

Courtaut F, Derangere V, Chevriaux A, Ladoire S, Cotte AK, Arnould L, Boidot R, Rialland M, Ghiringhelli F, Rebe C

Oncotarget. 2015 Sep 29;6(29):26651-62

Inhibition of the HER2 pathway by n-3 polyunsaturated fatty acids prevents breast cancer in fat-1 transgenic mice.

Zou Z, Bellenger S, Massey KA, Nicolaou A, Geissler A, Bidu C, Bonnotte B, Pierre AS, Minville-Walz M, Rialland M, Seubert J, Kang JX, Lagrost L, Narce M, Bellenger J

J Lipid Res. 2013 Dec;54(12):3453-63

Trans-10, cis-12 conjugated linoleic acid induced cell death in human colon cancer cells through reactive oxygen species-mediated ER stress.

Pierre AS, Minville-Walz M, Fevre C, Hichami A, Gresti J, Pichon L, Bellenger S, Bellenger J, Ghiringhelli F, Narce M, Rialland M

Biochim Biophys Acta. 2013 Apr;1831(4):759-68

Recent advances on stearoyl-Coa desaturase regulation in fatty liver diseases.

Narce M, Bellenger J, Rialland M, Bellenger S

Curr Drug Metab. 2012 Dec;13(10):1454-63.

Distinct regulation of stearoyl-CoA desaturase 1 gene expression by cis and trans C18:1 fatty acids in human aortic smooth muscle cells.

Minville-Walz M, Gresti J, Pichon L, Bellenger S, Bellenger J, Narce M, Rialland M

Genes Nutr. 2012 Apr;7(2):209-16

Mechanisms involved in lipid accumulation and apoptosis induced by 1-nitropyrene in Hepa1c1c7 cells.

Podechard N, Tekpli X, Catheline D, Holme JA, Rioux V, Legrand P, Rialland M, Fardel O, Lagadic-Gossmann D, Lecureur V

Toxicol Lett. 2011 Oct 30;206(3):289-99

The metabolic cascade leading to eicosanoid precursors - desaturases, elongases, and phospholipases A(2) - is altered in Zucker fatty rats.

Fevre C, Bellenger S, Pierre AS, Minville M, Bellenger J, Gresti J, Rialland M, Narce M, Tessier C

Biochim Biophys Acta. 2011 Jun;1811(6):409-17

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Dr RIALLAND Mickaël

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Les fonctions anticancéreuses des Th9 régulées par le métabolisme des acides gras

Fonctions anti-cancéreuses des lymphocytes Th9 et métabolisme des acides gras

Régulation de l’enzyme Elovl5 et son rôle dans le processus métastatique

L’ambivalence des agents anti-cancéreux 5-Fluorouracile et Gemcitabine sur les cellules myéloïdes suppressives sous contrôle des acides gras n-3

Rôle des « immune checkpoints » dans l'effet anti-tumoral de l'acide docosahexaénoique

Publications

Co-targeting TGF-β and PD-L1 sensitizes triple-negative breast cancer to experimental immunogenic cisplatin-eribulin chemotherapy doublet.