Fiche publication
Date publication
avril 2025
Journal
Arteriosclerosis, thrombosis, and vascular biology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr RIALLAND Mickaël
,
Dr PAIS DE BARROS Jean-Paul
,
Pr MASSON David
Tous les auteurs :
Leleu D, Pilot T, Mangin L, Van Dongen K, Proukhnitzky L, Denimal D, Samson M, Laubriet A, Steinmetz E, Rialland M, Pierre L, Groetz E, Pais de Barros JP, Gautier T, Thomas C, Masson D
Lien Pubmed
Résumé
During atherogenesis, macrophages turn into foam cells by engulfing lipids present within the atheroma plaques. The shift of foam cells toward proinflammatory or anti-inflammatory phenotypes, a critical step in disease progression, is still poorly understood. LXRs (liver X receptors) play a pivotal role in the macrophage response to lipid, promoting the expression of key genes of cholesterol efflux, mitigating intracellular cholesterol accumulation. LXRs also exert balanced actions on inflammation in human macrophages, displaying both proinflammatory and anti-inflammatory effects.
Mots clés
atherosclerosis, endothelial cells, homeostasis, macrophages, receptors, cytoplasmic and nuclear
Référence
Arterioscler Thromb Vasc Biol. 2025 04 10;:
