Fiche publication
Date publication
janvier 2026
Journal
Journal for immunotherapy of cancer
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GHIRINGHELLI François
,
Dr RIALLAND Mickaël
,
Dr VEGRAN Frédérique
,
Dr LIMAGNE Emeric
Tous les auteurs :
Groetz E, Perrey S, Baeza Garcia A, Dumont A, Pichon L, Kieu CTLV, Pierre L, Thomas C, Flavell R, Limagne E, Vegran F, Apetoh L, Ghiringhelli F, Rialland M
Lien Pubmed
Résumé
Stearoyl-CoA desaturase 1 (SCD1) is a key enzyme in fatty acid (FA) metabolism that catalyzes the addition of a cis double bond to palmitic and stearic saturated FAs, producing palmitoleic and oleic monounsaturated FAs, respectively. Interleukin (IL)9-secreting CD4 T-helper lymphocytes (Th9) exert antitumoral activity in preclinical cancer models. In the present study, we evaluated the role of SCD1 in Th9 differentiation and their antitumoral properties.
Mots clés
Adoptive cell therapy - ACT, Immunotherapy, Solid tumor, T-Lymphocytes
Référence
J Immunother Cancer. 2026 01 16;14(1):
