Environmentally Sensitive Fluorescent Sensors Based on Synthetic Peptides

Fiche publication


Date publication

avril 2010

Auteurs

Membres identifiés du Cancéropôle Est :
Dr CHOULIER Laurence


Tous les auteurs :
Choulier L, Enander K

Résumé

Biosensors allow the direct detection of molecular analytes, by associating a biological receptor with a transducer able to convert the analyte-receptor recognition event into a measurable signal. We review recent work aimed at developing synthetic fluorescent molecular sensors for a variety of analytes, based on peptidic receptors labeled with environmentally sensitive fluorophores. Fluorescent indicators based on synthetic peptides are highly interesting alternatives to protein-based sensors, since they can be synthesized chemically, are stable, and can be easily modified in a site-specific manner for fluorophore coupling and for immobilization on solid supports.

Référence

Sensors. 2010 Apr;10(4):3126-44