Triterpene Saponins from Cyclamen persicum
Fiche publication
Date publication
juillet 2010
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DUCHAMP Olivier
Tous les auteurs :
Mihei-Gaidi G, Pertuit D, Miyamoto T, Mirjolet JF, Duchamp O, Mitaine-Offer AC, Lacaille-Dubois MA
Lien Pubmed
Résumé
A new triterpene saponin 3-O-beta-D-glucopyranosyl-(1 -> 4)-alpha-L-arabinopyranosyl-16 alpha-hydroxy-13 beta,28-epoxy-oleanan-30-al (1), along with four known triterpene glycosides (2-5) were isolated from Cyclamen persicum. Their structures were characterized by a combination of 1D- and 2D-NMR (H-1-H-1 COSY, TOCSY, NOESY, HSQC, and HMBC) and MS spectrocopic data. The cytotoxicity of compounds 2 and 4 was evaluated using two human colon cancer cell lines HT-29 and HCT 116.
Référence
Nat Prod Commun. 2010 Jul;5(7):1023-5