Steroidal Saponins from Two Species of Dracaena
Fiche publication
Date publication
juillet 2010
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DUCHAMP Olivier
Tous les auteurs :
Kougan GB, Miyamoto T, Tanaka C, Paululat T, Mirjolet JF, Duchamp O, Sondengam BL, Lacaille-Dubois MA
Lien Pubmed
Résumé
Four new steroidal saponins (1-4) were isolated from the stem and bark of two species of Dracaena: deistelianosides A and B (1 and 2) from D. deisteliana and arboreasaponins A and B (3 and 4) front D. arborea. Six known saponins and one known sapogenin were also isolated. The structures of 1-4 were established as diosgenin 3-O-[3-O-sulfate-alpha-L-rhamnopyranosyl-(1 -> 4)]-beta-D-glueopyranoside (1), 1-O-beta-D-xylopyranosyl-(1 -> 2)-[alpha-L-rhamnopyranosyl-(1 -> 3)]-beta-D-fucopyranosyl(23S,24S)-spirosta-5,25(27)-diene-1 beta,3 beta,23 alpha,24 alpha-tetrol 24-O-alpha-L-arabinopyranoside (2), pennogenin-3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-[alpha-L-rhamnopyranosyl-(1 -> 3)]-[6-O-acetyl]-beta-D-glucopyranoside (3), and 24 alpha-hydroxypennogenin 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-[alpha-L-rhamnopyranosyl-(1 -> 3)]-beta-D-glucopyranoside (4) using extensive 1D and 2D NMR spectroscopic analyses and mass spectrometry. Cytotoxic activity of several of these compounds was evaluated against the HT-29 and HCT 116 human colon cancer cell lines.
Référence
J Nat Prod. 2010 Jul 23;73(7):1266-70.