An efficient one-pot four-step domino reaction for the synthesis of C2-substituted 3-methylcyclohex-2-enones.
Fiche publication
Date publication
septembre 2010
Auteurs
Membres identifiés du Cancéropôle Est :
Dr WAGNER Alain
Tous les auteurs :
Goncalves S, Maillos P, Nicolas M, Wagner A, Baati R
Lien Pubmed
Résumé
An efficient one-pot four-step domino reaction of substituted beta-ketoesters has been optimized giving rise to a large panel of C2-substituted 3-methylcyclohex-2-enones, an important scaffold for the preparation of various initiators for cationic or radical cyclizations. The developed methodology is quite general and applicable to a wide range of beta-ketoester substrates, allowing the introduction of various functionalities at the C2 position of the 3-methylcyclohex-2-enones, in good to excellent yields. (C) 2010 Elsevier Ltd. All rights reserved.
Référence
Tetrahedron. 2010 Sep 25;66(39):7856-60.