Radiofrequency ablation of unresectable liver tumors: factors associated with incomplete ablation or local recurrence.
Fiche publication
Date publication
octobre 2010
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MARCHAL Frédéric, Pr GERMAIN Adeline
Tous les auteurs :
Ayav A, Germain A, Marchal F, Tierris I, Laurent V, Bazin C, Yuan Y, Robert L, Brunaud L, Bresler L
Lien Pubmed
Résumé
BACKGROUND: Radiofrequency ablation (RFA) of liver tumors is associated with a risk of incomplete ablation or local recurrence. METHODS: One hundred sixty-eight patients with 311 unresectable liver tumors were included. Effects of different variables on incomplete ablation and local recurrence were analyzed. RESULTS: There were 132 hepatocellular carcinomas and 179 liver metastases. Tumor size was 24 (+/-13) mm. Two hundred twenty-six tumors were treated percutaneously, and 85 through open approach (associated with liver resection in 42 cases). There was no mortality. Major morbidity rate was 7%. Incomplete ablation and local recurrence rates were 14% and 18.6%. Follow-up was 29 months. On multivariate analysis, factors associated with incomplete ablation were tumor size (>30 mm vs 30 mm vs 65 years vs 30 mm. When tumor ablation is completely achieved, the main factor associated with local recurrence is tumor size >30 mm.
Référence
Am J Surg. 2010 Oct;200(4):435-9