Rho GTPases and exocytosis: what are the molecular links?
Fiche publication
Date publication
février 2011
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GASMAN Stéphane
Tous les auteurs :
Ory S, Gasman S
Lien Pubmed
Résumé
Delivery of proteins or lipids to the plasma membrane or into the extracellular space occurs through exocytosis, a process that requires tethering, docking, priming and fusion of vesicles, as well as F-actin rearrangements in response to specific extracellular cues. GTPases of the Rho family have been implicated as important regulators of exocytosis, but how Rho proteins control this process is an open question. In this review, we focus on molecular connections that drive Rho-dependent exocytosis in polarized and regulated exocytosis. Specifically, we present data showing that Rho proteins interaction with the exocyst complex and IQGAP mediates polarized exocytosis, whereas interaction with actin-binding proteins like N-WASP mediates regulated exocytosis.
Référence
Semin Cell Dev Biol. 2011 Feb;22(1):27-32