Interleukin-10 microsatellite variants and the risk of acute coronary syndrome among Tunisians.
Fiche publication
Date publication
février 2011
Auteurs
Membres identifiés du Cancéropôle Est :
Dr CORNILLET-LEFEBVRE Pascale
Tous les auteurs :
Ben-Hadj-Khalifa-Kechiche S, Cornillet-Lefebvre P, Gillot L, Abboud N, Ben-Khalfallah A, Addad F, Almawi WY, Mahjoub T
Lien Pubmed
Résumé
The objective of the study was to investigate the association of interleukin (IL)-10 promoter microsatellite polymorphisms, linked with altered IL-10 secretion, with the susceptibility to acute coronary syndrome (ACS) in adult Tunisian patients. We genotyped 291 ACS patients and 291 age-, gender- and ethnically matched control subjects for the microsatellites IL-10R [X78437.2g.5325CA(11_15)] and IL-10G [X78437.2g.8134CA(14_29)] by PCR-based assays. Haplotypes were reconstructed using maximum likelihood method. Regression analysis was used in determining the risk imparted by specific IL-10 genotypes and haplotypes. A significant decrease in IL-10G12 (24 CA repeats) (P
Référence
Int J Immunogenet. 2011 Feb;38(1):37-43