Polyethylenimine-carbon nanotube nanohybrids for siRNA-mediated gene silencing at cellular level.
Fiche publication
Date publication
avril 2011
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ZUBER Guy
Tous les auteurs :
Foillard S, Zuber G, Doris E
Lien Pubmed
Résumé
Carbon nanotubes (CNTs) covalently modified with low molecular weight polyethylenimine (PEI) are able to bind and deliver siRNA to cells with higher efficacy than a reference lipidic carrier. The performances of the nanohybrid are rationalized by the combination of the cell penetration and endosomal escape properties of CNTs and PEI, respectively.
Référence
Nanoscale. 2011 Apr;3(4):1461-4