How important are Rho GTPases in neurosecretion?
Fiche publication
Date publication
mai 2011
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BADER Marie-France, Dr GASMAN Stéphane
Tous les auteurs :
Momboisse F, Houy S, Ory S, Calco V, Bader MF, Gasman S
Lien Pubmed
Résumé
Rho GTPases are small GTP binding proteins belonging to the Ras superfamily which act as molecular switches that regulate many cellular function including cell morphology, cell to cell interaction, cell migration and adhesion. In neuronal cells, Rho GTPases have been proposed to regulate neuronal development and synaptic plasticity. However, the role of Rho GTPases in neurosecretion is poorly documented. In this review, we discuss data that highlight the importance of Rho GTPases and their regulators into the control of neurotransmitter and hormone release in neurons and neuroendocrine cells, respectively.
Référence
J Neurochem. 2011 May;117(4):623-31