SUVmax reduction improves early prognosis value of interim positron emission tomography scans in diffuse large B-cell lymphoma.

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Date publication

juillet 2011


Membres identifiés du Cancéropôle Est :

Tous les auteurs :
Casasnovas RO, Meignan M, Berriolo-Riedinger A, Bardet S, Julian A, Thieblemont C, Vera P, Bologna S, Briere J, Jais JP, Haioun C, Coiffier B, Morschhauser F


The prognostic value of interim positron emission tomography (PET) interpreted according to visual criteria is a matter of debate in diffuse large B-cell lymphoma (DLBCL). Maximal standardized uptake value reduction (DeltaSUVmax) may better predict outcome. To compare the prognostic value of both methods, we analyzed PET done at baseline (PET0) and after 2 (PET2) and 4 (PET4) cycles in 85 patients with high-risk DLBCL enrolled on a prospective multicenter trial. All images were centrally reviewed and interpreted visually according to the International Harmonization Project criteria and by computing DeltaSUVmax between PET0 and PET2 (DeltaSUVmaxPET0-2) or PET4 (DeltaSUVmaxPET0-4). Optimal cutoff to predict progression or death was 66% for DeltaSUVmaxPET0-2 and 70% for DeltaSUVmaxPET0-4. Outcomes did not differ significantly whether PET2 and PET4 were visually positive or negative. Inversely, DeltaSUVmaxPET0-2 analysis (> 66% vs 70% vs


Blood. 2011 Jul 7;118(1):37-43