[Evaluation of information about prophylactic treatment and management of hand-foot reactions caused by antiangiogenic therapies].
Fiche publication
Date publication
août 2011
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GEOFFROIS Lionnel, Dr GRANEL-BROCARD Florence
Tous les auteurs :
Guyot-Caquelin P, Geoffrois L, Barbaud A, Trechot P, Schmutz JL, Granel-Brocard F
Lien Pubmed
Résumé
BACKGROUND: Antiangiogenic agents may be associated with severe hand-foot reactions (HFR) requiring dose adjustment by oncologists. Many preventive and curative treatments are described in the literature but their efficacy has not been assessed in clinical trials. The aim of this study was to examine information given to patients about HFR and to evaluate compliance with prophylactic therapy for this complication. PATIENTS AND METHODS: Fifty-one patients receiving antiangiogenic therapy were followed up for a period of 19 months. At each visit, a dermatological examination was performed, compliance with topical treatment was assessed and advice was provided. At the end of the study, patients' perception of the information given was assessed by means of a questionnaire, completed either during consultations or by telephone. RESULTS: Although all patients were given information about HFR, 11 of 39 subjects claimed they had received no such information. There was no difference regarding compliance with topical treatment whether the information was provided by a dermatologist or an oncologist. Eleven patients consulted a podiatrist and nine patients used soft insoles. Twenty-two of 40 patients used topical treatments, with nine using such treatment from the outset. A statistically significant correlation was noted between compliance with preventive topical therapy and onset of HFR (P=0.028), and this finding merits confirmation in a larger-scale study. CONCLUSION: This study highlights the difficulties in implementing a programme to prevent HFR and suggests the value of providing multidisciplinary therapeutic education and of financing preventive and curative care.
Référence
Ann Dermatol Venereol. 2011 Aug-Sep;138(8-9):565-71