Experimental and Monte Carlo investigation of visible diffuse-reflectance imaging sensitivity to diffusing particle size changes in an optical model of a bladder wall.
Fiche publication
Date publication
novembre 2011
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BLONDEL Walter, Pr DAUL Christian, Pr WOLF Didier
Tous les auteurs :
Kalyagina N, Loschenov V, Wolf D, Daul C, Blondel W, Savelieva T
Lien Pubmed
Résumé
We have investigated the influence of scatterer size changes on the laser light diffusion, induced by collimated monochromatic laser irradiation, in tissue-like optical phantoms using diffuse-reflectance imaging. For that purpose, three-layer optical phantoms were prepared, in which nano- and microsphere size varied in order to simulate the scattering properties of healthy and cancerous urinary bladder walls. The informative areas of the surface diffuse-reflected light distributions were about 15x18 pixels for the smallest scattering particles of 0.05 mu m, about 21x25 pixels for the medium-size particles of 0.53 mu m, and about 25x30 pixels for the largest particles of 5.09 mu m. The computation of the laser spot areas provided useful information for the analysis of the light distribution with high measurement accuracy of up to 92%. The minimal stability of 78% accuracy was observed for superficial scattering signals on the phantoms with the largest particles. The experimental results showed a good agreement with the results obtained by the Monte Carlo simulations. The presented method shows a good potential to be useful for a tissue-state diagnosis of the urinary bladder.
Référence
. 2011 Nov;105(3):631-9.