Epiglottic Squamous Cell Carcinoma Showing Unexpected 18F-FDOPA Uptake on PET/CT Investigation.
Fiche publication
Date publication
mai 2015
Auteurs
Membres identifiés du Cancéropôle Est :
Pr NAMER Izzie-Jacques, Pr DEBRY Christian
Tous les auteurs :
Dietemann S, Debry C, Onea A, Namer IJ, Imperiale A
Lien Pubmed
Résumé
We report the unexpected findings of F-fluorodihydroxyphenylalanine (F-FDOPA) PET/CT performed in a patient with a history of ileal carcinoid. A focally increased F-FDOPA uptake was detected in the left side of the epiglottis corresponding to a laryngeal squamous cell carcinoma. Interestingly, uptake of 3-O-methyl-6-F-fluoro-L-dihydroxyphenylalanine, a metabolite of F-FDOPA, has been previously reported in both squamous cell carcinoma cell lines and the corresponding mouse tumor xenograft models. Although F-FDOPA is mainly used in patients with neuroendocrine tumors, F-FDOPA is not a neuroendocrine tumor-specific radiotracer.
Référence
Clin Nucl Med. 2015 May 25.