From elastin peptides to neuraminidase-1-dependent lactosylceramide generation.
Fiche publication
Date publication
janvier 2012
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DEBELLE Laurent, Dr DUCA Laurent, Pr MARTINY Laurent, Dr BRASSART Bertrand
Tous les auteurs :
Rusciani A, Duca L, Brassart B, Martiny L, Debelle L
Lien Pubmed
Résumé
Elastin peptides constitute a group of biologically active peptides derived from the fragmentation of insoluble elastin. These molecules, currently termed elastokines, have been shown to interact preferably with the elastin receptor complex. Recent data show that the sialidase activity of the neuraminidase-1 of this receptor is required for these peptides to induce their effects. As lactosylceramide generated at the plasma membrane by desialylation of the ganglioside GM(3) can be considered as a second messenger, we feel that this lipidic compound could mimic elastin peptides effects in physiopathological situations. (C) 2011 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.
Référence
. 2012 Jan;15(1):15-7.