A new microfluidic setup for precise control of the polymer nanoprecipitation process and lipophilic drug encapsulation.
Fiche publication
Date publication
janvier 2012
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MELY Yves, Dr MARCHIONI Eric
Tous les auteurs :
Anton N, Bally F, Serra CA, Ali A, Arntz Y, Mely Y, Zhao MJ, Marchioni E, Jakhmola A, Vandamme TF
Lien Pubmed
Résumé
A new microfluidic setup with impact-jet micromixers was built up and applied to control the nanoprecipitation process for generating polymeric nanoparticles and encapsulating a lipophilic drug. In contrast to a conventional nanoprecipitation processes in "bulk" phase, the microfluidic approach not only allows a continuous and controlled production of nanoparticles, but can also be used to manipulate and modify the nanoparticle size and the drug loading, by fine tuning the processing parameters. We developed a micromixer-assisted setup that can efficiently produce PMMA nanospheres, with a particle size of about 100 nm, and a narrow size distribution. Moreover, this setup enables a flow rate of the polymer phase as high as 1 mL min(-1), opening the possibilities of large-scale production. The obtained nanoparticles can encapsulate high levels of a lipophilic drug (ketoprofen) and release it over 4 h. Finally, the solvent and non-solvent flow rates can be used to adjust the physicochemical and encapsulating/release properties of these nanosystems, opening new possibilities for nanoparticle production by nanoprecipitation.
Référence
. 2012;8(41):10628-35.