Sequential FDG PET and MRI findings in a case of human herpes virus 6 limbic encephalitis.
Fiche publication
Date publication
juillet 2012
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BILGER Karin, Dr LIOURE Bruno, Pr NAMER Izzie-Jacques
Tous les auteurs :
Hubele F, Bilger K, Kremer S, Imperiale A, Lioure B, Namer IJ
Lien Pubmed
Résumé
A 50-year-old woman developed a human herpes virus 6 limbic encephalitis characterized by memory loss and somnolence, 3 weeks after a cord blood-derived stem cell transplantation. Sequential scalp electroencephalogram failed to detect seizure activity. Cerebrospinal fluid polymerase chain reaction assay demonstrated human herpes virus 6 deoxyribonucleic acid (positive, 3.74 log). Acute phase FDG PET imaging showed bilateral intense FDG uptake in both hippocampi and amygdalae. After antiviral treatment (gancyclovir followed by foscarnet), neurologic symptoms disappear gradually. Late phase FDG PET imaging showed a regression in FDG uptake representing hippocampal hypometabolism because of hippocampal sclerosis.
Référence
Clin Nucl Med. 2012 Jul;37(7):716-7